Agonist-induced phosphorylation of cAR1, the major chemoattractant receptor of Dictyostelium, causes lowered affinity of the purified receptor: possible direct mechanism for desensitization of G-protein coupled receptors (GPCRs)

被引：0

作者：

Xiao, Z ^{[1
]}

Yao, YH ^{[1
]}

Long, Y ^{[1
]}

Devreotes, PN ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

来源：

FASEB JOURNAL | 1998年 / 12卷 / 08期

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

879

引用

页码：A1462 / A1462

页数：1

共 6 条

[1] Desensitization of G-protein-coupled receptors -: Agonist-induced phosphorylation of the chemoattractant receptor cAR1 lowers its intrinsic affinity for cAMP
Xiao, Z
Yao, YH
Long, Y
Devreotes, P
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (03) : 1440 - 1448
[2] AGONIST-INDUCED LOSS OF LIGAND-BINDING IS CORRELATED WITH PHOSPHORYLATION OF CAR1, A G-PROTEIN-COUPLED CHEMOATTRACTANT RECEPTOR FROM DICTYOSTELIUM
CATERINA, MJ
DEVREOTES, PN
BORLEIS, J
HERELD, D
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (15) : 8667 - 8672
[3] Evidence of an important and direct role for protein kinase C in agonist-induced phosphorylation leading to desensitization of the angiotensin AT(1A) receptor
Balmforth, AJ
Shepherd, FH
Warburton, P
Ball, SG
BRITISH JOURNAL OF PHARMACOLOGY, 1997, 122 (07) : 1469 - 1477
[4] Enhanced expression of G protein-coupled receptor kinase 2 selectively increases the sensitivity of A2A adenosine receptors to agonist-induced desensitization
Mundell, SJ
Luty, JS
Willets, J
Benovic, JL
Kelly, E
BRITISH JOURNAL OF PHARMACOLOGY, 1998, 125 (02) : 347 - 356
[5] Effect of G protein-coupled receptor kinase 2 on the sensitivity of M4 muscarinic acetylcholine receptors to agonist-induced internalization and desensitization in NG108-15 cells
Holroyd, EW
Szekeres, PG
Whittaker, RD
Kelly, E
Edwardson, JM
JOURNAL OF NEUROCHEMISTRY, 1999, 73 (03) : 1236 - 1245
[6] Phosphorylation of cortactin at Y446 residue is required for G protein-coupled receptor agonist-induced nuclear export and degradation of p21Cip1.
Janjanam, J.
Rao, G. N.
MOLECULAR BIOLOGY OF THE CELL, 2016, 27

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