Cerebrospinal fluid isoprostane shows oxidative stress in patients with multiple sclerosis

被引：78

作者：

Greco, A

Minghetti, L

Sette, G

Fieschi, C

Levi, G

机构：

[1] Ist Super Sanita, Lab Pathophysiol, I-00161 Rome, Italy

[2] Univ Rome La Sapienza, Dept Neurol Sci, I-00185 Rome, Italy

来源：

NEUROLOGY | 1999年 / 53卷 / 08期

关键词：

8-epi-prostaglandin F-2 alpha; prostaglandin E-2; CSF; MS; human; lipid peroxidation; oxidative stress;

D O I：

10.1212/WNL.53.8.1876

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The CSF level of the isoprostane 8-epi-prostaglandin (PG)-F-2 alpha (a reliable marker of oxidative stress in vivo) was three times higher in subjects with definite MS than in a benchmark group of subjects with other neurologic diseases. This increase was not correlated with that of PGE, levels, measured as an index of cyclooxygenase activity, and was much lower in steroid-treated patients. The levels of 8-epi-PGF(2 alpha) were moderately correlated with the degree of disability.

引用

页码：1876 / 1879

页数：4

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