Association of Alzheimer's Disease With APOE and IL-1α Gene Polymorphisms

Apolipoprotein E (ApoE) gene polymorphisms are thought to be the most important genetic risk factor in the pathogenesis of late onset and sporadic Alzheimer's disease (AD). Moreover, interleukin-1 (IL-1) is found to be associated with the pathogenesis of AD. In this research, 2, 3, and 4 polymorphisms of ApoE gene and C889T polymorphism of IL-1 gene were genotyped in patients with AD and controls. Genotyping was performed by real-time polymerase chain reaction. 3/3 and 3/4 genotype frequencies were significantly higher in control and case groups, respectively. While 3 allele frequencies were significantly higher in the control group, 2 and 4 allele frequencies were significantly higher among the cases with AD. No difference was found between the groups according to C889T polymorphism of IL-1. In conclusion, we demonstrated that there was a strong association between ApoE 4 allele and AD, while there was no relation with IL-1 C889T polymorphisms for this study.