A420983, a novel, small molecule inhibitor of LCK prevents allograft rejection

被引:23
|
作者
Waegell, W
Babineau, M
Hart, M
Dixon, K
McRae, B
Wallace, C
Leach, M
Ratnofsky, S
Belanger, A
Hirst, G
Rossini, A
Appel, M
Mordes, J
Greiner, D
Banerjee, S
机构
[1] Abbott Biores Ctr, Worcester, MA 01605 USA
[2] Univ Massachusetts, Ctr Med, Worcester, MA 01003 USA
关键词
D O I
10.1016/S0041-1345(02)02909-3
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:1411 / 1417
页数:7
相关论文
共 50 条
  • [1] A-770041, a novel and selective small-molecule inhibitor of Lck, prevents heart allograft rejection
    Stachlewitz, RF
    Hart, MA
    Bettencourt, B
    Kebede, T
    Schwartz, A
    Ratnofsky, SE
    Calderwood, DJ
    Waegell, WO
    Hirst, GC
    [J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2005, 315 (01): : 36 - 41
  • [2] A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection
    Borhani, DW
    Calderwood, DJ
    Friedman, MM
    Hirst, GC
    Li, BQ
    Leung, AKW
    McRae, B
    Ratnofsky, S
    Ritter, K
    Waegell, W
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (10) : 2613 - 2616
  • [3] Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection
    Burchat, A
    Borhani, DW
    Calderwood, DJ
    Hirst, GC
    Li, BQ
    Stachlewitz, RF
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (01) : 118 - 122
  • [4] Dipeptide boronic acid, a novel proteasome inhibitor, prevents islet-allograft rejection
    Wu, YL
    Han, B
    Luo, HY
    Shi, GX
    Wu, JP
    [J]. TRANSPLANTATION, 2004, 78 (03) : 360 - 366
  • [5] A proteasome inhibitor effectively prevents mouse heart allograft rejection
    Luo, HY
    Wu, YL
    Qi, SJ
    Wan, XC
    Chen, HF
    Wu, JP
    [J]. TRANSPLANTATION, 2001, 72 (02) : 196 - 202
  • [6] A novel small-molecule compound targeting CCR5 and CXCR3 prevents acute and chronic allograft rejection
    Akashi, S
    Sho, M
    Kashizuka, H
    Hamada, K
    Ikeda, N
    Kuzumoto, Y
    Tsurui, Y
    Nomi, T
    Mizuno, T
    Kanehiro, H
    Hisanaga, M
    Ko, S
    Nakajima, Y
    [J]. TRANSPLANTATION, 2005, 80 (03) : 378 - 384
  • [7] Small molecule Lck inhibitors promote long term allograft survival.
    Hart, M
    Stachlewitz, R
    Perkins, M
    Babineau, M
    Hirst, G
    Waegell, W
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2004, 4 : 287 - 287
  • [8] A novel small molecule inhibitor of MRCK prevents radiation driven invasion in glioblastoma
    Birch, J.
    Gilmour, L. D.
    Strathdee, K.
    Bower, J.
    McKinnon, H.
    Drysdale, M.
    Olson, M.
    Chalmers, A. D.
    [J]. RADIOTHERAPY AND ONCOLOGY, 2018, 127 : S1282 - S1283
  • [9] A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma
    Birch, Joanna L.
    Strathdee, Karen
    Gilmour, Lesley
    Vallatos, Antoine
    McDonald, Laura
    Kouzeli, Ariadni
    Vasan, Richa
    Qaisi, Abdulrahman Hussain
    Croft, Daniel R.
    Crighton, Diane
    Gill, Kathryn
    Gray, Christopher H.
    Konczal, Jennifer
    Mezna, Mokdad
    McArthur, Duncan
    Schuttelkopf, Alexander W.
    McConnell, Patricia
    Sime, Mairi
    Holmes, William M.
    Bower, Justin
    McKinnon, Heather J.
    Drysdale, Martin
    Olson, Michael F.
    Chalmers, Anthony J.
    [J]. CANCER RESEARCH, 2018, 78 (22) : 6509 - 6522
  • [10] ORAL LEFLUNOMIDE PREVENTS SMALL-BOWEL ALLOGRAFT-REJECTION IN THE RAT
    HE, G
    LEE, TDG
    BITTERSUERMANN, H
    THEAL, M
    WRIGHT, J
    MACDONALD, AS
    MCALISTER, VC
    [J]. TRANSPLANTATION PROCEEDINGS, 1994, 26 (03) : 1613 - 1613