CNS demyelination and quadrivalent HPV vaccination

被引：83
|
作者：
Sutton, I. [1 ,2 ]
Lahoria, R. [3 ]
Tan, I. L. [2 ]
Clouston, P. [4 ]
Barnett, M. H. [1 ,3 ]
机构：
[1] Univ Sydney, Brain & Mind Res Inst, Camperdown, NSW 2050, Australia
[2] St Vincents Hosp, Dept Neurol, Darlinghurst, NSW 2010, Australia
[3] St George Hosp, Kogarah, NSW, Australia
[4] Westmead Hosp, Westmead, NSW 2145, Australia
来源：
MULTIPLE SCLEROSIS JOURNAL | 2009年 / 15卷 / 01期
关键词：
demyelination; multiple sclerosis; human papillomavirus; vaccination; HEPATITIS-B VACCINATION; MULTIPLE-SCLEROSIS; EVENTS;
D O I：
10.1177/1352458508096868
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Vaccination is generally considered safe in patients with multiple sclerosis (MS). We report five patients who presented with multifocal or atypical demyelinating syndromes within 21 days of immunization with the quadrivalent human papilloma virus (HPV) vaccine, Gardasil (R). Although the target population for vaccination, young females, has an inherently high risk for MS, the temporal association with demyelinating events in these cases may be explained by the potent immuno-stimulatory properties of HPV virus-like particles which comprise the vaccine. A prospective case-control study of patients with MS or clinically isolated demyelinating syndromes receiving the Gardasil (R) vaccine may provide relevant safety data in this population. Multiple Sclerosis 2009; 15: 116-119. http://msj.sagepub.com
引用
收藏
页码：116 / 119
页数：4
相关论文
共 50 条
  • [1] A case report of quadrivalent human papilloma virus vaccination and CNS demyelination: coincidence or a causal relationship?
    Bouktsi, M.
    Paschalidou, M.
    Milonas, I.
    MULTIPLE SCLEROSIS, 2009, 15 (09): : S87 - S87
  • [2] Quadrivalent HPV vaccination: no increased risk of VTE?
    Reactions Weekly, 2014, 1512 (1) : 4 - 4
  • [3] Quadrivalent HPV vaccination does not increase risk of MS
    Nature Reviews Neurology, 2015, 11 (2) : 68 - 68
  • [4] COST-EFFECTIVENESS OF QUADRIVALENT HPV VACCINATION IN FINLAND
    Vaananen, J. J. P.
    Herse, F.
    Korkeamaki, J.
    Parvinen, P. M. T.
    Remy, O.
    VALUE IN HEALTH, 2008, 11 (06) : A431 - A431
  • [5] Quadrivalent HPV Vaccination and the Risk of Adverse Pregnancy Outcomes
    Scheller, Nikolai M.
    Pasternak, Bjorn
    Molgaard-Nielsen, Ditte
    Svanstrom, Henrik
    Hviid, Anders
    NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (13): : 1223 - 1233
  • [6] HPV QUADRIVALENT VACCINE Reduction in subsequent HPV related disease was unrelated to vaccination
    Fiala, Christian
    BRITISH MEDICAL JOURNAL, 2012, 344
  • [7] Quadrivalent HPV vaccination reactions More hype than harm
    Douglas, Robert J.
    AUSTRALIAN FAMILY PHYSICIAN, 2009, 38 (03) : 139 - +
  • [8] A case of fulminant neuromyelitis optica associated with quadrivalent HPV vaccination
    Menge, T.
    Saleh, A.
    Aktas, O.
    Hartung, H. P.
    Methner, A.
    Kieseier, B. C.
    MULTIPLE SCLEROSIS, 2009, 15 (09): : S152 - S152
  • [9] Modelling the effects of quadrivalent Human Papillomavirus (HPV) vaccination in Puerto Rico
    Ortiz, Ana Patricia
    Ortiz-Ortiz, Karen J.
    Rios, Moraima
    Laborde, Jose
    Kulkarni, Amit
    Pillsbury, Matthew
    Lauschke, Andreas
    Monsanto, Homero A.
    Marques-Goyco, Cecile
    PLOS ONE, 2017, 12 (11):
  • [10] No autoimmune safety signal after vaccination with quadrivalent HPV vaccine Gardasil?
    Tomljenovic, L.
    Shaw, C. A.
    JOURNAL OF INTERNAL MEDICINE, 2012, 272 (05) : 514 - 515
12345