Effect of antiplatelet therapy and platelet function testing on hemorrhagic and thrombotic complications in patients with cerebral aneurysms treated with the pipeline embolization device: a review and meta-analysis

被引:92
|
作者
Skukalek, Susana L. [1 ,2 ]
Winkler, Anne M. [3 ]
Kang, Jian [4 ]
Dion, Jacques E. [5 ,6 ]
Cawley, C. Michael [5 ,6 ]
Webb, Adam [6 ,7 ]
Dannenbaum, Mark J. [8 ]
Schuette, Albert J. [9 ]
Asbury, Bill [10 ]
Tong, Frank C. [5 ,6 ]
机构
[1] Emory Clin, Dept Neurosurg, Atlanta, GA 30322 USA
[2] Emory Clin, Dept Radiol, Atlanta, GA 30322 USA
[3] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA
[4] Emory Rollins Sch Publ Hlth, Dept Biostat & Bioinformat, Atlanta, GA USA
[5] Emory Univ, Sch Med, Dept Radiol, Atlanta, GA 30322 USA
[6] Emory Univ, Sch Med, Dept Neurosurg, Atlanta, GA USA
[7] Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA
[8] Univ Texas Houston, Dept Neurosurg, Houston, TX USA
[9] Tripler Army Med Ctr, Dept Neurosurg, Honolulu, HI 96859 USA
[10] Emory Univ Hosp, Atlanta, GA 30322 USA
关键词
Aneurysm; Complication; Flow Diverter; SINGLE-CENTER EXPERIENCE; TERM-FOLLOW-UP; INTRACRANIAL ANEURYSMS; ENDOVASCULAR TREATMENT; RECONSTRUCTION; STENT;
D O I
10.1136/neurintsurg-2014-011145
中图分类号
R445 [影像诊断学];
学科分类号
100207 ;
摘要
Purpose The pipeline embolization device (PED) necessitates dual antiplatelet therapy (APT) to decrease thrombotic complications while possibly increasing bleeding risks. The role of APT dose, duration, and response in patients with hemorrhagic and thromboembolic events warrants further analysis. Methods A PubMed and Google Scholar search from 2009 to 2014 was performed using the following search terms individually or in combination: pipeline embolization device, aneurysm(s), and flow diversion, excluding other flow diverters. Review of the bibliographies of the retrieved articles yielded 19 single and multicenter studies. A statistical meta-analysis between aspirin (ASA) dose (low dose 160mg, high dose 300mg), loading doses of APT agents, post-PED APT regimens, and platelet function testing (PFT) with hemorrhagic or thrombotic complications was performed. Results ASA therapy for 6months post-PED was associated with increased hemorrhagic events. High dose ASA 6months post-PED was associated with fewer thrombotic events compared with low dose ASA. Post-PED clopidogrel for 6months demonstrated an increased incidence of symptomatic thrombotic events. Loading doses of ASA plus clopidogrel demonstrated a decreased incidence of permanent symptomatic hemorrhagic events. PFT did not show a statistically significant relationship with symptomatic hemorrhagic or thrombotic complications. Conclusions High dose ASA >6months is associated with fewer permanent thrombotic and hemorrhagic events. Clopidogrel therapy 6months is associated with higher rates of thrombotic events. Loading doses of ASA and clopidogrel were associated with a decreased incidence of hemorrhagic events. PFT did not have any significant association with symptomatic events.
引用
收藏
页码:58 / 65
页数:8
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