Smart block copolymers of PVP and an alkylated PVP derivative: synthesis, characterization, thermoresponsive behaviour and self-assembly

被引：14
|
作者：
Giliomee, Johnel [1 ]
Pfukwa, Rueben [1 ]
Gule, Nonjabulo P. [1 ]
Klumperman, Bert [1 ]
机构：
[1] Univ Stellenbosch, Dept Chem & Polymer Sci, Private Bag X1, ZA-7602 Matieland, South Africa
来源：
POLYMER CHEMISTRY | 2016年 / 7卷 / 05期
基金：
新加坡国家研究基金会;
关键词：
PHASE-BEHAVIOR; RESPONSIVE POLYMERS; TRIBLOCK COPOLYMERS; N-VINYLPYRROLIDONE; VESICLES; DIBLOCK; POLY(N-VINYLPYRROLIDONE); MICELLES; GLYCOL); LCST;
D O I：
10.1039/c5py01609f
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Stimuli responsive block copolymers of biocompatible poly(3-ethyl-N-vinylpyrrolidone) and poly(N-vinylpyrrolidone), i.e. EPVP-PVP, were readily synthesized via RAFT-mediated polymerization. The thermoresponsive behaviour and temperature induced self-assembly, in aqueous solutions, was studied using various spectroscopic and microscopy techniques. We obtained different morphologies, i. e. spherical and cylindrical micelles, and vesicles, via temperature induced self-assembly, of aqueous solutions of a single diblock copolymer by simply adjusting the solution concentration. This study establishes the biocompatible EPVP/PVP combination as a versatile stimuli responsive block copolymer system suitable for applications in drug delivery.
引用
收藏
页码：1138 / 1146
页数：9
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