Cytochrome P450 epoxygenase CYP2J2 and the risk of coronary artery disease

被引：44
|
作者：
Spiecker, Martin
Liao, James K.
机构：
[1] Brigham & Womens Hosp, Cambridge, MA 02139 USA
[2] St Josef Hosp Bochum, Dept Med 2, D-44791 Bochum, Germany
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 2006年 / 16卷 / 06期
关键词：
D O I：
10.1016/j.tcm.2006.04.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cytochrome P450 (CYP) enzyme 2J2, an epoxygenase predominantly expressed in the heart, metabolizes arachidonic acid to biologically active eicosanoids. One of the CYP2J2 products, 11,12-epoxyeicosatrienoic acid, has several vasoprotective effects. A frequent promoter polymorphism of CYP2J2 decreases gene expression and is associated with coronary artery disease. This association supports the vascular protective role of CYP-derived eicosanoids in cardiovascular disease.
引用
收藏
页码：204 / 208
页数：5
相关论文
共 50 条
  • [1] Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2
    Spiecker, M
    Darius, H
    Hankeln, T
    Soufi, M
    Sattler, AM
    Schaefer, JR
    Node, K
    Börgel, J
    Mügge, A
    Lindpaintner, K
    Huesing, A
    Maisch, B
    Zeldin, DC
    Liao, JK
    CIRCULATION, 2004, 110 (15) : 2132 - 2136
  • [2] Expression of the cytochrome P450 epoxygenase CYP2J2 in human monocytic leukocytes
    Nakayama, Kaeko
    Nitto, Takeaki
    Inoue, Teruo
    Node, Koichi
    LIFE SCIENCES, 2008, 83 (9-10) : 339 - 345
  • [3] EXPRESSION OF THE CYTOCHROME P450 EPOXYGENASE CYP2J2 IN HUMAN MONOCYTIC LEUKOCYTES
    Nakayama, Kaeko
    Nitto, Takeaki
    Inoue, Teruo
    Node, Koichi
    JOURNAL OF VASCULAR RESEARCH, 2009, 46 : 199 - 199
  • [4] CYTOCHROME P450 EPOXYGENASE 2J2 (CYP2J2) AND IT'S METABOLITES ARE UPREGULATED IN PREECLAMPSIA
    Herse, Florian
    Hubel, Carl A.
    Huppertz, Berthold
    LaMarca, Babbette B.
    Sargent, Ian
    Luft, Friedrich C.
    Schunck, Wolf-Hagen
    Muller, Dominik N.
    Staff, Anne Cathrine
    Dechend, Ralf
    PLACENTA, 2011, 32 (09) : A97 - A97
  • [5] Cytochrome P450 Epoxygenase 2J2 (CYP2J2) and it's Metabolites are Upregulated in Preeclampsia
    Herse, Florian
    Hubel, Carl A.
    Huppertz, Berthold
    Park, Joon-Keun
    LaMarca, Babbette
    Sargent, Ian L.
    Luft, Friedrich C.
    Staff, Anne C.
    Schunck, Wolf-Hagen
    Muller, Dominik N.
    Dechend, Ralf
    HYPERTENSION, 2010, 56 (05) : E91 - E91
  • [6] Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice
    Chen, Guangzhi
    Wang, Peihua
    Zhao, Gang
    Xu, Gang
    Gruzdev, Artiom
    Zeldin, Darryl C.
    Wang, Dao Wen
    PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2011, 96 (1-4) : 63 - 71
  • [7] Crohn's disease and ulcerative colitis are associated with a promoter polymorphism of the cytochrome P450 epoxygenase Cyp2j2 gene
    Otte, JM
    Spiecker, M
    Jagiello, P
    Brand, S
    Felderbauer, P
    Griga, T
    Epplen, JT
    Schmitz, F
    Schmidt, WE
    GASTROENTEROLOGY, 2005, 128 (04) : A446 - A447
  • [8] Role of cytochrome epoxygenase (CYP2J2) in the pathophysiology of coronary artery disease in South Indian population
    Tantray, Javeed Ahmad
    Reddy, K. Pratap
    Jamil, Kaiser
    Yerra, Shiva Kumar
    INDIAN HEART JOURNAL, 2019, 71 (01) : 60 - 64
  • [9] Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart
    Wu, S
    Moomaw, CR
    Tomer, KB
    Falck, JR
    Zeldin, DC
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (07) : 3460 - 3468
  • [10] Synergistic effect of cytochrome P450 epoxygenase CYP2J2*7 polymorphism with smoking on the onset of premature myocardial infarction
    Liu, Ping-Yen
    Li, Yi-Heng
    Chao, Ting-Hsing
    Wu, Hua-Lin
    Lin, Li-Jen
    Tsai, Liang-Miin
    Chen, Jyh-Hong
    ATHEROSCLEROSIS, 2007, 195 (01) : 199 - 206
12345