Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker diabetic fatty rats

被引：55
|
作者：
Shimabukuro, M
Zhou, YT
Lee, Y
Unger, RH
机构：
[1] UNIV TEXAS,SW MED CTR,DEPT INTERNAL MED,GIFFORD LABS,DALLAS,TX 75235
[2] DEPT VET AFFAIRS MED CTR,DALLAS,TX 75235
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 237卷 / 02期
关键词：
D O I：
10.1006/bbrc.1997.7140
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Because troglitazone, like leptin, lowers the triglyceride (TG) content of pancreatic islets, we searched for other leptinomimetic actions, Leptin upregulates the expression of uncoupling protein-2 (UCP-2) mRNA in islets of normal rats, but has no effect in islets of obese Zucker Diabetic Fatty (ZDF) rats with mutated leptin receptors. We report here that troglitazone also increases the UCP-2/beta-actin mRNA ratio by 115% in wild type ZDF rats and by 400% in obese ZDF rats. (C) 1997 Academic Press.
引用
收藏
页码：359 / 361
页数：3
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