In vivo protection by broadly neutralizing HIV antibodies

被引：38
|
作者：
van Gils, Merit J. [1 ]
Sanders, Rogier W. [1 ,2 ]
机构：
[1] Univ Amsterdam, Acad Med Ctr, Lab Expt Virol, Dept Med Microbiol,Ctr Infect & Immun Amsterdam, NL-1012 WX Amsterdam, Netherlands
[2] Cornell Univ, Weill Med Coll, Dept Microbiol & Immunol, New York, NY 10021 USA
来源：
TRENDS IN MICROBIOLOGY | 2014年 / 22卷 / 10期
关键词：
D O I：
10.1016/j.tim.2014.08.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Passive immunization studies, including a recent one by Pegu et al., have repeatedly shown that HIV-specific broadly neutralizing antibodies (bnAbs) protect rhesus macaques from HIV acquisition. In vitro neutralization potency and in vivo protection correlate very strongly, supporting the quest for an HIV vaccine that induces potent bnAbs.
引用
收藏
页码：550 / 551
页数：2
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