Long-Term Management of Gout Nonpharmacologic and Pharmacologic Therapies

被引：16

作者：

Chaichian, Yashaar ^{[1
]}

Chohan, Saima ^{[1
]}

Becker, Michael A. ^{[1
]}

机构：

[1] Univ Chicago, Rheumatol Sect, Chicago, IL 60637 USA

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2014年 / 40卷 / 02期

关键词：

Gout; Hyperuricemia; Risk reduction; Urate-lowering therapy; Allopurinol; Febuxostat; Uricosuric agents; Pegloticase; URIC-ACID LEVEL; NUTRITION EXAMINATION SURVEY; URATE-LOWERING THERAPY; 3RD NATIONAL-HEALTH; SERUM URATE; RISK-FACTORS; ANTIHYPERURICEMIC THERAPY; INCIDENT GOUT; HYPERSENSITIVITY SYNDROME; CONVENTIONAL TREATMENT;

D O I：

10.1016/j.rdc.2014.01.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Gout is a common disorder with clinical signs and symptoms resulting from inflammatory responses to monosodium urate crystals deposited in tissues from extracellular fluids saturated for urate. Long-term management of gout focuses on nonpharmacologic and pharmacologic means to achieve and maintain serum urate levels in a subsaturating range. Despite a firm understanding of gout pathophysiology, means to achieve certain diagnosis, and a variety of effective therapies, treatment outcomes remain suboptimal. In this review, available nonpharmacologic and pharmacologic therapies for chronic gout are discussed and a framework is provided for successful achievement and maintenance of goal-range serum urate levels.

引用

页码：357 / +

页数：19

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