Canned bluefin tuna, an in vitro cardioprotective functional food potentially safer than commercial fish oil based pharmaceutical formulations

被引：8

作者：

Tenore, Gian Carlo ^{[1
]}

Calabrese, Giorgio ^{[1
]}

Ritieni, Alberto ^{[1
]}

Campiglia, Pietro ^{[2
]}

Giannetti, Daniela ^{[1
]}

Novellino, Ettore ^{[1
]}

机构：

[1] Univ Napoli Federico II, Dept Pharm, I-80131 Naples, Italy

[2] Univ Salerno, Dept Pharmaceut & Biomed Sci, I-84084 Salerno, Italy

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2014年 / 71卷

关键词：

Canned fish; Bluefin tuna; n-3; PUFA; Cardiomyocytes; Oxidative stress; POLYUNSATURATED FATTY-ACIDS; DOCOSAHEXAENOIC ACID; EICOSAPENTAENOIC ACID; CARDIOVASCULAR HEALTH; OMEGA-3; CONSUMPTION; MENHADEN; HUMANS; ESTERS; LIPIDS;

D O I：

10.1016/j.fct.2014.06.016

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Commercial canned fish species typical in the Italian market were evaluated for their lipid profile. Bluefin tuna samples showed the highest content in omega-3 fatty acids (n-3 PUFA) among the canned fish samples analyzed. Tests on H9C2 cardiomyocytes revealed that bluefin tuna n-3 PUFA may responsible for a significant cell protection against both physiological and doxorubicin-induced oxidative stress. Analogous tests performed by incubating cardiac cells with n-3 PUFA ethyl esters, of which most of fish oil pharmaceutical formulations (FOPF) are based, showed cytotoxicity at high doses. Our results highlighted that n-3 PUFA contents in a 50 g canned bluefin tuna portion would be almost equivalent to and potentially safer than those of 1 FOPF capsule (1000 mg)/die usually suggested for hyperlipidaemic subjects. Thus, Italian commercial canned bluefin tuna could be indicated as a functional food with potential health benefits for the prevention and care of cardiovascular disorders. (C) 2014 Elsevier Ltd. All rights reserved.

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页码：231 / 235

页数：5