High-dimensional solid-liquid phase diagrams involving compounds and polymorphs

被引:9
|
作者
Wibowo, C
Samant, KD
Ng, KM
机构
[1] Hong Kong Univ Sci & Technol, Dept Chem Engn, Hong Kong, Hong Kong, Peoples R China
[2] Univ Massachusetts, Dept Chem Engn, Amherst, MA 01003 USA
关键词
D O I
10.1002/aic.690481009
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
A systematic procedure for the generation and visualization of high-dimensional isobaric phase diagrams for systems exhibiting compound formation and/or polymorphism is presented. Such phase diagrams are useful in synthesizing crystallization-based separation processes for systems involving compounds and polymorphs, which are common in the production of pharmaceuticals. Polythermal as well as isothermal phase diagrams of multicomponent systems can be generated. Examples are provided to illustrate the procedure.
引用
收藏
页码:2179 / 2192
页数:14
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