Retinal pigment epithelium (RPE) cytoskeleton in vivo and in vitro

被引：34
|
作者：
Bonilha, Vera L. [1 ]
机构：
[1] Cleveland Clin, Lerner Coll Med, Cole Eye Inst, Dept Ophthalm Res, Cleveland, OH 44195 USA
来源：
EXPERIMENTAL EYE RESEARCH | 2014年 / 126卷
关键词：
etinal pigment epithelium; cytoskeleton; polarity; ADHESION MOLECULE-C; CELL-LINE; ARPE-19; CELLS; MYOSIN-VIIA; VERTEBRATE RETINAS; APICAL PROJECTIONS; BINDING-PROTEIN; TIGHT JUNCTIONS; EXPRESSION; LOCALIZATION;
D O I：
10.1016/j.exer.2013.09.015
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
The retinal pigment epithelium (RPE) constitutes a monolayer of cuboidal cells that interact apically with the interphotoreceptor matrix (IPM) and outer segments of the photoreceptor cells and basally with the subjacent Bruch's membrane. This highly polarized structure is maintained by the cytoskeleton of individual cells and their interactions at the basolateral junctional complexes that stabilize this epithelial structure. This RPE complex network of filaments, tubules and associated proteins is modeled by the cellular environment, the RPE intercellular interactions, and by its interactions with the extracellular matrix. This is a review of the key features of the RPE cytoskeleton in vivo and in vitro. (C) 2013 Elsevier Ltd. All rights reserved.
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收藏
页码：38 / 45
页数：8
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