Prenatal alcohol exposure: Implications for cardiovascular function in the fetus and beyond

被引:18
|
作者
Parkington, Helena C. [1 ]
Coleman, Harold A. [1 ]
Wintour, E. Marelyn [1 ]
Tare, Marianne [1 ]
机构
[1] Monash Univ, Dept Physiol, Melbourne, Vic 3168, Australia
关键词
alcohol and programming; alcohol in pregnancy; arterial stiffness; endothelial function; fetal alcohol; vascular function; MATERNAL NUTRITIONAL-STATUS; CEREBRAL-BLOOD-FLOW; LOW-PROTEIN DIET; ETHANOL EXPOSURE; ENDOTHELIAL FUNCTION; ADULT SHEEP; MATRIX METALLOPROTEINASES; ARTERIAL STIFFNESS; NEPHRON NUMBER; YOUNG-ADULTS;
D O I
10.1111/j.1440-1681.2009.05342.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1. The effects of heavy maternal alcohol consumption during pregnancy on cognitive and behavioural performance and craniofacial malformations in the offspring have been studied extensively. In contrast, the impact of maternal alcohol intake on the cardiovascular system of the offspring and the effects of more modest consumption have received very scant consideration. 2. Adverse conditions in the pre- and neonatal periods can have a profound legacy on offspring health, including the risk of cardiovascular disease. Prenatal alcohol exposure can modulate vascular reactivity, including endothelial and smooth muscle function. 3. Other effects of prenatal alcohol exposure are emerging, including impairment of nephrogenesis and kidney function and increased arterial stiffness. The impact of even modest prenatal alcohol exposure on cardiovascular health in the offspring remains to be determined. 4. It is envisaged that the culmination of reduced renal and vascular capacity will render the offspring more vulnerable to cardiovascular disease with ageing and exposure to additional insults and lifestyle factors.
引用
收藏
页码:E91 / E98
页数:8
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