Challenges and Opportunities in Implementing Pharmacogenetic Testing in Clinical Settings

被引：21
|
作者：
Chang, Wan-Chun [1 ,2 ]
Tanoshima, Reo [1 ,2 ]
Ross, Colin J. D. [2 ,4 ]
Carleton, Bruce C. [1 ,2 ,3 ]
机构：
[1] Univ British Columbia, Fac Med, Dept Pediat, Div Translat Therapeut, Vancouver, BC V6H 3V4, Canada
[2] BC Childrens Hosp, Res Inst, Vancouver, BC V5Z 4H4, Canada
[3] BC Childrens Hosp, Res Inst, Pharmaceut Outcomes Programme, Vancouver, BC V5Z 4H4, Canada
[4] Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC V6T 1Z3, Canada
来源：
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021 | 2021年 / 61卷
关键词：
pharmacogenomics; pharmacogenetics; clinical implementation; adverse drug reaction; drug safety; drug effectiveness; COST-EFFECTIVENESS ANALYSIS; STEVENS-JOHNSON-SYNDROME; TOXIC EPIDERMAL NECROLYSIS; ADVERSE DRUG-REACTIONS; CONSORTIUM CPIC GUIDELINE; ELECTRONIC HEALTH RECORDS; DECISION-SUPPORT; GOUT PATIENTS; CARBAMAZEPINE; THERAPY;
D O I：
10.1146/annurev-pharmtox-030920-025745
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The clinical implementation of pharmacogenetic biomarkers continues to grow as new genetic variants associated with drug outcomes are discovered and validated. The number of drug labels that contain pharmacogenetic information also continues to expand. Published, peer-reviewed clinical practice guidelines have also been developed to support the implementation of pharmacogenetic tests. Incorporating pharmacogenetic information into health care benefits patients as well as clinicians by improving drug safety and reducing empiricism in drug selection. Barriers to the implementation of pharmacogenetic testing remain. This review explores current pharmacogenetic implementation initiatives with a focus on the challenges of pharmacogenetic implementation and potential opportunities to overcome these challenges.
引用
收藏
页码：65 / 84
页数：20
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