Molecular insights into the immunopathogenesis of follicular lymphoma

被引：52
|
作者：
Stamatopoulos, K [1 ]
Kosmas, C
Belessi, C
Stavroyianni, N
Kyriazopoulos, P
Papadaki, T
机构：
[1] Univ Athens, Sch Med, Dept Med 1, GR-10679 Athens, Greece
[2] Laikon Gen Hosp, Athens, Greece
[3] Evangelismos Med Ctr, Hemopathol Unit, Athens, Greece
来源：
IMMUNOLOGY TODAY | 2000年 / 21卷 / 06期
关键词：
D O I：
10.1016/S0167-5699(00)01650-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Follicular lymphoma is caused by the transformation of a germinal-center-derived B cell with a t(14;18) chromosomal translocation. The distribution of somatic mutations within immunoglobulin genes indicates that follicular-lymphoma cells can interact with antigen. In addition, nonimmunoglobulin genes such as BCL6 seem to undergo somatic hypermutation. Here, Kostas Stamatopoulos and colleagues relate the molecular data about immunoglobulin genes and the protooncogenes BCL2 and BCL6 to the pathogenesis and evolution of follicular lymphoma.
引用
收藏
页码：298 / 305
页数：8
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