Liposomal doxorubicin-loaded chitosan microspheres capable of controlling release of doxorubicin for anti-cancer chemoembolization: in vitro characteristics

被引：0
|
作者：
Kim, Hyeong-Min [1 ]
Lee, Ga-Hyeon [1 ]
Kuh, Hyo-Jeong [2 ]
Kwak, Byung Kook [3 ]
Lee, Jaehwi [1 ]
机构：
[1] Chung Ang Univ, Coll Pharm, Seoul 156756, South Korea
[2] Catholic Univ Korea, Coll Med, Dept Biomed Sci, Seoul 137701, South Korea
[3] Chung Ang Univ Hosp, Dept Radiol, Seoul 156755, South Korea
来源：
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2013年 / 23卷 / 03期
关键词：
Liposomal doxorubicin; Chemoembolization; Chitosan; Release; DRUG-RELEASE; EMBOLIZATION;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The aim of this study was to develop liposomal doxorubicin-loaded chitosan microspheres (LDox-CSMS) for anti-cancer chemoembolization. LDox-CSMS and doxorubicin-loaded CSMS (Dox-CSMS) devoid of liposomal carrier were prepared with an emulsification and cross-linking method. Various stirring rates were required to obtain large fractions of CSMS in the size range of 300-500 mu m. Drug loading amounts were considerably influenced by the amount of doxorubicin-loaded liposomes added. Drug release from LDox-CSMS was controlled by the drug loading amount, which was varied by the addition of liposomal doxorubicin. These results indicate that LDox-CSMS can be used as an advanced chemoembolic agent that can control drug release behaviors.
引用
收藏
页码：283 / 286
页数：4
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