Preparation and Spectroscopic of Vanadyl (II) Vitamin D3 Amino Acid Mixed Complexes as Insulin Mimetic Drug

被引：0
|
作者：
Aljuhani, Enas [1 ]
Alsuhaibani, Amnah M. A. [2 ]
El-Didamony, A. M. [3 ]
Hassan, N. [4 ]
Taleb, Sameh Abo [4 ]
Refat, Moamen S. [4 ,5 ]
机构：
[1] Umm Al Qura Univ, Fac Appl Sci, Dept Chem, PO 9168, Mecca 21955, Saudi Arabia
[2] Princess Nourah Bint Abdulrahman Univ, Nutr & Food Sci Dept, Home Econ Coll, Riyadh, Saudi Arabia
[3] Zagazig Univ, Dept Chem, Fac Sci, Zagazig, Egypt
[4] Port Said Univ, Dept Chem, Fac Sci, Port Said, Egypt
[5] Taif Univ, Fac Sci, Chem Dept, POB 888, Al Hawiah 21974, Taif, Saudi Arabia
来源：
SPECTROSCOPY AND SPECTRAL ANALYSIS | 2019年 / 39卷 / 07期
关键词：
Insulin alternative; Diabetes; Drug; VO2+ ion; Vitamin D-3; Amino acid; Spectroscopic; GLUCOSE; LEAVES;
D O I：
10.3964/j.issn.1000-0593(2019)07-2316-09
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
A new six intraperitoneal injection insulin-mimetic vanadyl (II) compounds [(VD3-1) (VO+2) (AA(n)(-1))] (where (n= 1 similar to 6) ; AA(1) =isoleucine, AA(2) =threonine, AA(3) =proline, AA(4) =phenylalanine, AA(5) =lysine and AA(6) =glutamine) were synthesized by the chemical reactions between vitamin D-3 (VD3) VOSO4 and amino acids (AA(n)) with equal molar ratio 1 : 1 : 1 in neutralized media. The structures of these complexes were elucidated by spectroscopic methods like, infrared and solid reflectance spectroscopes. Magnetic moments and electronic spectra reveal square pyramid geometrical structure of the complexes. The infrared spectra assignments of these complexes revealed that the chelation towards vanadyl (IV) ions existed via deprotonation of the hydroxyl group of VD3 drug ligand and so amino acids act as bidentate ligand via N-amino and O-carboxylate groups. The anti-diabetic efficiency of these complexes were evaluated against streptozotocin induced diabetic male albino rats.
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收藏
页码：2316 / 2324
页数：9
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