An expeditious synthesis of pyrrolo[3,4-d]-pyrimidine-2,4-dione from uracil

被引：0

作者：

Zimmerman, MN ^{[1
]}

Nemeroff, NH ^{[1
]}

Bock, CW ^{[1
]}

Bhat, KL ^{[1
]}

机构：

[1] Philadelphia Univ, Sch Sci & Hlth, Dept Chem, Philadelphia, PA 19144 USA

来源：

HETEROCYCLES | 2000年 / 53卷 / 01期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, practical and cost effective synthesis of the title compound has been realized from uracil. The key step is the construction of the pyrrole ring using tosylmethylisocyanide (TosMIC) methodology. The structure of uracil, reaction intermediates and the final product were investigated using density functional calculations.

引用

页码：205 / 211

页数：7

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