HLA-DQA1 in autochthonous Basques: Description of a genocline for the DQA1*0201 allele in Europe

被引：8
|
作者：
Iriondo, M
Manzano, C
delaRua, C
机构：
[1] Animali Biologia Eta Genetika Saila, Zientzi Fakultatea, Euskal Herriko Unibertsitatea, Sarriena s/n
来源：
INTERNATIONAL JOURNAL OF LEGAL MEDICINE | 1996年 / 109卷 / 04期
关键词：
HLA-DQA1; Basques; population genetics; genocline;
D O I：
10.1007/BF01225516
中图分类号：
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号：
0301 ; 10 ;
摘要：
A total of 250 autochthonous Basque individuals were tested in the HLA-DQA1 system, and the allele frequency distribution found was significantly different from that of any other European population. The differences centre mainly on the alleles DQA1*0201 and DQA1*0501: for the former the Basques have the highest frequency described anywhere in the world (f = 0.210) and for the latter they have the lowest frequency in Europe (f = 0.204). For the allele DQA1*0201 a genocline is also described in Europe with the Basques and Finno-Ugric populations basically at the extremes. The genocline reflects the isolation of the Basque population since prehistoric times, and supports existing linguistic, archaeological and genetic data.
引用
收藏
页码：181 / 185
页数：5
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