Serpins in Hemostasis as Therapeutic Targets for Bleeding or Thrombotic Disorders

被引：7

作者：

Bianchini, Elsa P. ^{[1
]}

Auditeau, Claire ^{[1
]}

Razanakolona, Mahita ^{[1
]}

Vasse, Marc ^{[1
,2
]}

Borgel, Delphine ^{[1
,3
]}

机构：

[1] Univ Paris Saclay, Inst Natl Sante & Rech Medicale, HITh, UMR S1176, Le Kremlin Bicetre, France

[2] Hop Foch, Serv Biol Clin, Suresnes, France

[3] Hop Necker Enfants Malad, AP HP, Lab Hematol Biol, Paris, France

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2021年 / 7卷

关键词：

serpin (serine proteinase inhibitor); antithrombin (AT); protein Z-dependent protease inhibitor (ZPI); plasminogen activator inhibitor 1 (PAI-1); therapy; protease nexin I (PN-1); PLASMINOGEN-ACTIVATOR INHIBITOR-1; PROTEIN-C; SYNTHETIC PENTASACCHARIDE; HEMOPHILIA-A; ANTITHROMBIN; HEPARIN; ANTICOAGULANT; FONDAPARINUX; DEFICIENCY; SYSTEM;

D O I：

10.3389/fcvm.2020.622778

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Bleeding and thrombotic disorders result from imbalances in coagulation or fibrinolysis, respectively. Inhibitors from the serine protease inhibitor (serpin) family have a key role in regulating these physiological events, and thus stand out as potential therapeutic targets for modulating fibrin clot formation or dismantling. Here, we review the diversity of serpin-targeting strategies in the area of hemostasis, and detail the suggested use of modified serpins and serpin inhibitors (ranging from small-molecule drugs to antibodies) to treat or prevent bleeding or thrombosis.

引用

页数：7

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