Social Impairments in Chromosome 22q11.2 Deletion Syndrome (22q11.2DS): Autism Spectrum Disorder or a Different Endophenotype?

被引：57
|
作者：
Angkustsiri, Kathleen [1 ,2 ]
Goodlin-Jones, Beth [2 ,3 ]
Deprey, Lesley [2 ]
Brahmbhatt, Khyati [2 ,3 ]
Harris, Susan [2 ]
Simon, Tony J. [2 ,3 ]
机构：
[1] Univ Calif Davis, Dept Pediat, Med Ctr, Sacramento, CA 95817 USA
[2] Univ Calif Davis, MIND Inst, Sacramento, CA 95817 USA
[3] Univ Calif Davis, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA
来源：
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2014年 / 44卷 / 04期
关键词：
Autism; ASD; 22q11.2 deletion syndrome; Velocardiofacial syndrome; CARDIO-FACIAL-SYNDROME; CHILDREN; SYMPTOMS; SCHIZOPHRENIA; MICRODELETION; INDIVIDUALS; COGNITION; PROFILE; THOUGHT; ADULTS;
D O I：
10.1007/s10803-013-1920-x
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
High prevalence of autism spectrum disorders (ASD) has been reported in 22q11.2DS, although this has been based solely on parent report measures. This study describes the presence of ASD using a procedure more similar to that used in clinical practice by incorporating history (Social Communication Questionnaire) AND a standardized observation measure (Autism Diagnostic Observation Schedule) and suggests that ASD is not as common as previously reported in 22q11.2DS. Differences in methodology, along with comorbid conditions such as anxiety, likely contribute to false elevations in ASD prevalence and information from multiple sources should be included in the evaluation of ASD.
引用
收藏
页码：739 / 746
页数：8
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