Genetic subtypes of HIV type 1 in Hungary

被引：11
|
作者：
Mezei, M
Balog, K
Takács, M
Tóth, G
Gyuris, A
Segesdi, J
Bakos, A
Vödrös, D
Bánhegyi, D
Berencsi, G
Minárovits, J
机构：
[1] Natl Ctr Epidemiol, Microbiol Res Grp, H-1529 Budapest, Hungary
[2] Natl Ctr Epidemiol, Dept Virol, H-1966 Budapest, Hungary
[3] Eotvos Lorand Univ, Dept Genet, H-1088 Budapest, Hungary
[4] St Laszlo Hosp, H-1450 Budapest, Hungary
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2000年 / 16卷 / 06期
关键词：
D O I：
10.1089/088922200308927
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We examined the diversity of HIV-1 subtypes in 11 adults from Hungary, using the heteroduplex mobility assay (HMA) and DNA sequencing, HMA results showed that HIV-1 gp120 sequences from 10 patients were of subtype B, whereas 1 patient, infected in Africa, carried a subtype C strain. DNA sequencing confirmed the HMA results and revealed a high intrasubtype diversity in the C2V3 region of env in different clade B isolates, which suggests multiple introduction of subtype B to Hungary. This study shows that subtype B is the predominant HIV-1 clade in Hungary.
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收藏
页码：513 / 516
页数：4
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