Liver development in zebrafish (Danio rerio)

被引：120
|
作者：
Tao, Ting [1 ]
Peng, Jinrong [1 ]
机构：
[1] Zhejiang Univ, Coll Anim Sci, Hangzhou 310029, Zhejiang, Peoples R China
来源：
JOURNAL OF GENETICS AND GENOMICS | 2009年 / 36卷 / 06期
基金：
中国国家自然科学基金;
关键词：
zebrafish; model organism; liver development; endoderm; FISH BRACHYDANIO-RERIO; HEPATITIS-B-VIRUS; DIGESTIVE ORGANS; EMBRYONIC-DEVELOPMENT; TRANSCRIPTION FACTOR; BILIARY DEVELOPMENT; GENE-EXPRESSION; HEART FORMATION; MULTIPLE ROLES; ENDODERM;
D O I：
10.1016/S1673-8527(08)60121-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Liver is one of the largest internal organs in the body and its importance for metabolism, detoxification and homeostasis has been well established. In this review, we summarized recent progresses in studying liver initiation and development during embryogenesis using zebrafish as a model system. We mainly focused on topics related to the specification of hepatoblasts from endoderm, the formation and growth of liver bud, the differentiation of hepatocytes and bile duct cells from hepatoblasts, and finally the role of mesodermal signals in controlling liver development in zebrafish.
引用
收藏
页码：325 / 334
页数：10
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