Pattern and Dynamics of Distant Metastases in Metastatic Colorectal Cancer

被引:62
|
作者
Holch, Julian Walter [1 ,2 ]
Demmer, Maximilian [1 ]
Lamersdorf, Charlotte [1 ]
Michl, Marlies [1 ,2 ]
Schulz, Christoph [1 ,2 ]
von Einem, Jobst Christian [1 ,2 ]
Modest, Dominik Paul [1 ,2 ]
Heinemann, Volker [1 ,2 ]
机构
[1] Ludwig Maximilians Univ Munchen, Univ Hosp Grosshadern, Comprehens Canc Ctr Munich, Dept Med Oncol, Munich, Germany
[2] German Canc Res Ctr, German Canc Consortium, DKTK, Partner Site Munich, Munich, Germany
关键词
Metastatic colorectal cancer; Localization; Incidence; Development of metastases; Metachronous metastases; Synchronous metastases; LIVER METASTASES; COLON; EPIDEMIOLOGY; PROGNOSIS; MANAGEMENT; SURVIVAL; PROPOSAL; IMPACT; LUNG;
D O I
10.1159/000454687
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: Few studies report the incidence of metastatic patterns in colorectal cancer. Furthermore, little is known about dynamic aspects of these metastases during the course of disease. Methods: This retrospective cohort study involved 385 patients who received anti-tumor treatment at our institution (Department of Medical Oncology, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Germany) for metastatic colorectal adenocarcinoma between 2007 and 2014. We reviewed all available imaging results of these patients to document the presence and detailed localization of metastases. Results: Most of the evaluated patients were initially diagnosed with metastases in the liver (70%), followed by the lungs (24%), distant lymph nodes (16%), and peritoneum (15%), besides rare anatomical sites (< 5%). Colon and rectal cancer as well as synchronous and metachronous metastases differed with regard to the pattern of individual metastatic sites. The median time to first progressive disease (PD) with new metastases was 12.6 months. The time intervals between first and second as well as second and third PD with new metastases were comparable with 10.5 and 10.8 months, respectively. At initial diagnosis, the mean number of metastatic sites was 1.4 and increased to 2.6 at the third PD with new metastases. For patients with initially one metastatic site, the mean number increased to 2.2. Conclusion: The present analysis provides detailed information on the pattern and evolution of colorectal cancer metastases over time. Thus, it may establish the basis for prospective future research in this field. (C) 2017 S. Karger GmbH, Freiburg
引用
收藏
页码:70 / 75
页数:6
相关论文
共 50 条
  • [1] Pattern of distant metastases in colorectal cancer: a SEER based study
    Qiu, Miaozhen
    Hu, Jianming
    Yang, Dajun
    Cosgrove, David Peter
    Xu, Ruihua
    [J]. ONCOTARGET, 2015, 6 (36) : 38658 - 38666
  • [2] Transcriptomic Differences between Primary Colorectal Adenocarcinomas and Distant Metastases Reveal Metastatic Colorectal Cancer Subtypes
    Kamal, Yasmin
    Schmit, Stephanie L.
    Hoehn, Hannah J.
    Amos, Christopher I.
    Frost, H. Robert
    [J]. CANCER RESEARCH, 2019, 79 (16) : 4227 - 4241
  • [3] COLORECTAL-CANCER - MANAGING DISTANT METASTASES
    LANGER, B
    [J]. CANADIAN JOURNAL OF SURGERY, 1985, 28 (05) : 419 - 421
  • [4] The association of immunosurveillance and distant metastases in colorectal cancer
    Jacob, Sven
    Jurinovic, Vindi
    Lampert, Christopher
    Pretzsch, Elise
    Kumbrink, Joerg
    Neumann, Jens
    Ren Haoyu
    Renz, Bernhard W.
    Kirchner, Thomas
    Guba, Markus O.
    Werner, Jens
    Angele, Martin K.
    Boesch, Florian
    [J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2021, 147 (11) : 3333 - 3341
  • [5] The association of immunosurveillance and distant metastases in colorectal cancer
    Sven Jacob
    Vindi Jurinovic
    Christopher Lampert
    Elise Pretzsch
    Jörg Kumbrink
    Jens Neumann
    Ren Haoyu
    Bernhard W. Renz
    Thomas Kirchner
    Markus O. Guba
    Jens Werner
    Martin K. Angele
    Florian Bösch
    [J]. Journal of Cancer Research and Clinical Oncology, 2021, 147 : 3333 - 3341
  • [6] Origins of lymphatic and distant metastases in human colorectal cancer
    Naxerova, Kamila
    Reiter, Johannes G.
    Brachtel, Elena
    Lennerz, Jochen K.
    van de Wetering, Marc
    Rowan, Andrew
    Cai, Tianxi
    Clevers, Hans
    Swanton, Charles
    Nowak, Martin A.
    Elledge, Stephen J.
    Jain, Rakesh K.
    [J]. SCIENCE, 2017, 357 (6346) : 55 - 60
  • [7] Discordant RAS status between primary and metastatic colorectal cancer and predicted pattern of metastases
    Lau, K. S.
    Lam, K. O.
    Choy, T. S.
    Shek, W. H.
    Chung, L. P.
    Leung, T. W.
    [J]. ANNALS OF ONCOLOGY, 2015, 26 : 46 - 46
  • [8] Metastatic hepatic actinomycosis masquerading as distant metastases of ovarian cancer
    Kim, Young Sun
    Lee, Bo Yon
    Jung, Min Hyung
    [J]. JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2012, 38 (03) : 601 - 604
  • [9] Impact of stereotactic body radiotherapy on colorectal cancer with distant metastases
    Hiraki, Masayuki
    Nishimura, Junichi
    Ohtsuka, Masahisa
    Shiomi, Hiroya
    Uemura, Mamoru
    Haraguchi, Naotsugu
    Hata, Taishi
    Hayashi, Taro
    Takemasa, Ichiro
    Mizushima, Tsunekazu
    Isohashi, Fumiaki
    Yoshioka, Yasuo
    Ogawa, Kazuhiko
    Doki, Yuichiro
    Mori, Masaki
    Yamamoto, Hirofumi
    [J]. ONCOLOGY REPORTS, 2014, 31 (02) : 795 - 799
  • [10] Prognostic marker profiles for risk of distant metastases in colorectal cancer
    Neumann, J.
    Reu, S.
    Kirchner, T.
    [J]. PATHOLOGE, 2012, 33 (01): : 39 - 44