Substitutions of zinc in mesoporous silicate-based glasses and their physicochemical and biological properties

Mesoporous bioactive silicate-based glasses in the system of (38-x)CaO-xZnO-58SiO(2)-4P(2)O(5) (mol.%), where x varies between 0 and 20, have been prepared by the sol-gel method. The influence of zinc addition on glass physicochemical properties, degradability and apatite-formation ability was comprehensively investigated. The nitrogen adsorption/desorption results confirmed the glasses mesoporous structure. The degradability of glass was studied in Tris-HCl, the addition of zinc would lead to a decrease. Furthermore, the glass apatite-formation ability was assessed by immersion of samples in simulated body fluid (SBF) solution for up to 7 days. The changes in glass surface morphology and composition were detected using X-ray diffraction (XRD), scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDS) and fourier transform infrared spectroscopy (FTIR). It was observed that the apatite precipitation rate slowed down with the increase of zinc, suggesting that the incorporation of zinc could be a promising route to regulate the dissolution and apatite formation of silicate-based glasses.