Microwave-assisted hydrothermal rapid synthesis of amorphous calcium phosphate nanoparticles and hydroxyapatite microspheres using cytidine 5′-triphosphate disodium salt as a phosphate source

被引：33
|
作者：
Zhao, Jing [1 ]
Zhu, Ying-Jie [1 ]
Cheng, Guo-Feng [1 ]
Ruan, Yin-Jie [1 ]
Sun, Tuan-Wei [1 ]
Chen, Feng [1 ]
Wu, Jin [1 ]
Zhao, Xin-Yu [1 ]
Ding, Guan-Jun [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
来源：
MATERIALS LETTERS | 2014年 / 124卷
基金：
中国国家自然科学基金;
关键词：
Nanocrystalline materials; Biomaterials; Nanoparticles; Microwave; Hydroxyapatite; PHOSPHORUS SOURCE; DRUG;
D O I：
10.1016/j.matlet.2014.03.054
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Calcium phosphates are important biomaterials for biomedical applications. Herein, we report microwave-assisted hydrothermal rapid synthesis of amorphous calcium phosphate (ACP) nanoparticles and hydroxyapatite (HAP) microspheres using cytidine 5'-triphosphate disodium salt as a phosphate source. This synthesis method does not need any surfactant and is very rapid (1 min at 150 degrees C). The pH value has a significant effect on the morphology and crystallinity of the product. Aggregated ACP nanoparticles, hierarchically nanostructured solid HAP micro-Spheres and hollow HAP microspheres are obtained at pH 7.0, 5.0 and 4.3, respectively. The as-prepared products are characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FFIR) and thermogravimetric (TG) analysis. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：208 / 211
页数：4
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