Enantioselective total synthesis of sagittacin E and related natural products

被引：3
|
作者：
Abe, Hideki [1 ,2 ]
Fujimaki, Mitsuru [1 ]
Nakagawa, Eri [1 ]
Kobayashi, Toyoharu [1 ]
Ito, Hisanaka [1 ]
机构：
[1] Tokyo Univ Pharm & Life Sci, Sch Life Sci, 1432-1 Horinouchi, Hachioji, Tokyo 1920392, Japan
[2] Japan Womens Univ, Dept Chem & Biol Sci, Fac Sci, Bunkyo Ku, 2-8-1 Mejirodai, Tokyo 1128681, Japan
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 48期
关键词：
EREMOPHILANE-TYPE SESQUITERPENOIDS; CATALYZED ALLYLIC OXIDATION; ASYMMETRIC EPOXIDATION; CHIRAL KETONES; OLEFINS; ALCOHOLS; TRIOXIDE; COMPLEX;
D O I：
10.1039/c8cc03438a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The first enantioselective total synthesis of eremophilane-type sesquiterpenoids, sagittacin E and related natural products, was achieved. This synthesis features an asymmetric desymmetrization by Shi asymmetric epoxidation, intramolecular aldol-type cyclization, allylic oxidation of a 1,4-diene compound, and stereoselective epoxidation.
引用
收藏
页码：6165 / 6168
页数：4
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