Structure-activity relationships in the acronycine series

被引:0
|
作者
Michel, S
Seguin, E
Tillequin, F
机构
[1] Univ Paris 05, Fac Sci Pharmaceut & Biol, Pharmacol Lab, CNRS,UMR 8638, F-75006 Paris, France
[2] Univ Rouen, Fac Pharm, Lab Pharmacognosie, F-76183 Rouen, France
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D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Acronycine is active against a broad spectrum of solid tumors. Structure activity relationships demonstrated the crucial role of the 1,2-double bond. A hypothesis of bioactivation into 1,2-epoxide led to the development of a series of 1,2-dihydroxy-1,2-dihydroacronycine and 1,2-dihydroxy-1,2-dihydrobenzo[b]acronycine diesters that exhibited an increased potency when compared with the parent compound.
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页码:1689 / 1700
页数:12
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