Scaffolds for tissue engineering of cardiac valves

被引:126
|
作者
Jana, S. [1 ]
Tefft, B. J. [1 ]
Spoon, D. B. [1 ]
Simari, R. D. [1 ]
机构
[1] Mayo Clin, Div Cardiovasc Dis, Rochester, MN 55905 USA
关键词
Heart valve; Tissue engineering; Scaffold; Fiber; Hydrogel; VALVULAR INTERSTITIAL CELL; ENDOTHELIAL GROWTH-FACTOR; POLY(GLYCEROL SEBACATE) SCAFFOLDS; DECELLULARIZED HEART-VALVE; SMOOTH-MUSCLE-CELLS; IN-VIVO EVALUATION; EXTRACELLULAR-MATRIX; CROSS-LINKING; MECHANICAL-PROPERTIES; CUSHION FORMATION;
D O I
10.1016/j.actbio.2014.03.014
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Tissue engineered heart valves offer a promising alternative for the replacement of diseased heart valves avoiding the limitations faced with currently available bioprosthetic and mechanical heart valves. In the paradigm of tissue engineering, a three-dimensional platform - the so-called scaffold - is essential for cell proliferation, growth and differentiation, as well as the ultimate generation of a functional tissue. A foundation for success in heart valve tissue engineering is a recapitulation of the complex design and diverse mechanical properties of a native valve. This article reviews technological details of the scaffolds that have been applied to date in heart valve tissue engineering research. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:2877 / 2893
页数:17
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