Association of Heparin-binding EGF-like Growth Factor Polymorphisms With Necrotizing Enterocolitis in Preterm Infants

被引：6

作者：

Ma, Fei ^{[1
]}

Li, Sitao ^{[1
]}

Hao, Hu ^{[1
]}

Gao, Pingmin ^{[2
]}

Dai, Yiheng ^{[2
]}

Himani, Chhetri ^{[1
]}

Liu, Weidong ^{[2
]}

Gao, Xiaoyan ^{[2
]}

Xiao, Xin ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Neonatol, 26 Yuancun Erheng Rd, Guangzhou 510655, Guangdong, Peoples R China

[2] Foshan Women & Children Hosp, Dept Neonatol, Foshan, Peoples R China

来源：

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | 2018年 / 66卷 / 04期

关键词：

heparin-binding epidermal growth factor; single-nucleotide polymorphism; necrotizing enterocolitis; preterm infants; FACTOR GENE; PREECLAMPSIA; MICE;

D O I：

10.1097/MPG.0000000000001753

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) protects the intestines from injury in experimental necrotizing enterocolitis (NEC). We hypothesized that polymorphisms in the HB-EGF gene lead to low HB-EGF production in peripheral blood and increased risk of NEC in the Chinese Han population. To test this hypothesis, 30 NEC patients and 80 control subjects were selected. Five HB-EGF single-nucleotide polymorphisms (SNPs) and its plasma levels were measured by genotyping and enzyme-linked immunosorbent assay, respectively. Only 1 out of the 5 SNPs showed a notable result. The notable SNP (rs4912711) was associated with NEC in its minor allele frequency and its G/T genotype distribution. In addition, plasma HB-EGF levels were reduced especially the G/T genotype in NEC patients. Our data suggest that if validated in larger studies screening for HB-EGF SNPs/genotypes and plasma levels may be useful as a risk factor for NEC in the future.

引用

页码：E99 / E102

页数：4

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