Long-Term Neurodevelopmental and Functional Outcomes of Infants Born Very Preterm and/or with a Very Low Birth Weight

被引：23

作者：

Hollanders, Jonneke J. ^{[1
]}

Schaefer, Nina ^{[1
]}

van der Pal, Sylvia M. ^{[2
]}

Oosterlaan, Jaap ^{[3
]}

Rotteveel, Joost ^{[1
]}

Finken, Martijn J. J. ^{[1
,9
]}

Hille, E. T. M. ^{[4
]}

de Groot, C. H. ^{[4
]}

Kloosterboer-Boerrigter, H. ^{[4
]}

den Ouden, A. L. ^{[4
]}

Rijpstra, A. ^{[4
]}

Verloove-Vanhorick, S. P. ^{[4
]}

Vogelaar, J. A. ^{[4
]}

Kok, J. H. ^{[5
]}

Ilsen, A. ^{[5
]}

van der Lans, M. ^{[5
]}

Boelen-van der Loo, W. J. C. ^{[5
]}

Lundqvist, T. ^{[5
]}

Heymans, H. S. A. ^{[5
]}

Duiverman, E. J. ^{[6
]}

Geven, W. B. ^{[6
]}

Duiverman, M. L. ^{[6
]}

Geven, L. I. ^{[6
]}

Vrijlandt, E. J. L. E. ^{[6
]}

Mulder, A. L. M. ^{[7
]}

Gerver, A. ^{[7
]}

Kollee, L. A. A. ^{[8
]}

Reijmers, L. ^{[8
]}

Sonnemans, R. ^{[8
]}

Wit, J. M. ^{[9
]}

Dekker, F. W. ^{[9
]}

Weisglas-Kuperus, N. ^{[10
]}

Keijzer-Veen, M. G. ^{[10
]}

van der Heijden, A. J. ^{[10
]}

van Goudoever, J. B. ^{[10
]}

van Weissenbruch, M. M. ^{[11
]}

Cranendonk, A. ^{[11
]}

Delemarre-van de Waal, H. A. ^{[11
]}

de Groot, L. ^{[11
]}

Samsom, J. F. ^{[11
]}

de Vries, L. S. ^{[12
]}

Rademaker, K. J. ^{[12
]}

Moerman, E. ^{[12
]}

Voogsgeerd, M. ^{[12
]}

de Kleine, M. J. K. ^{[13
]}

Andriessen, P. ^{[13
]}

Dielissen-van Helvoirt, C. C. M. ^{[13
]}

Mohamed, I. ^{[13
]}

van Straaten, H. L. M. ^{[14
]}

Baerts, W. ^{[14
]}

机构：

[1] Vrije Univ Amsterdam Med Ctr, Dept Pediat, Room KTC 4-033,Postbus 7057, NL-1007 MB Amsterdam, Netherlands

[2] TNO, Child Hlth, Leiden, Netherlands

[3] Vrije Univ Amsterdam, Dept Clin Neuropsychol, Amsterdam, Netherlands

[4] TNO Qual Life, Leiden, Netherlands

[5] Emma Childrens Hosp AMC, Amsterdam, Netherlands

[6] Univ Hosp Groningen, Beatrix Childrens Hosp, Groningen, Netherlands

[7] Univ Hosp Maastricht, Maastricht, Netherlands

[8] Radboud Univ Nijmegen Med Ctr, Nijmegen, Netherlands

[9] Leiden Univ, Med Ctr, Leiden, Netherlands

[10] Univ Med Ctr Rotterdam, Erasmus MC Sophia Childrens Hosp, Rotterdam, Netherlands

[11] Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands

[12] UMC, Wilhelmina Childrens Hosp, Utrecht, Netherlands

[13] Maxima Med Ctr, Veldhoven, Netherlands

[14] Isala Clin, Zwolle, Netherlands

[15] Royal Effatha Guyot Grp, Zoetermeer, Netherlands

[16] Assoc Parents Premature Babies, Amsterdam, Netherlands

来源：

NEONATOLOGY | 2019年 / 115卷 / 04期

关键词：

Prematurity; Low gestational age; Adolescents; IQ; Behavior; Health status; Neuromotor functioning; YOUNG-ADULTS BORN; GESTATIONAL-AGE INFANTS; CHILDREN BORN; PSYCHOPATHOLOGY; PROJECT; HEALTH; COHORT; LIFE;

D O I：

10.1159/000495133

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Background: Birth weight (BW) is often used as a proxy for gestational age (GA) in studies on preterm birth. Recent findings indicate that, in addition to perinatal outcomes, subjects born very preterm (VP; GA < 32 weeks) differ from those with a very low birth weight (VLBW; BW < 1,500 g) in postnatal growth up to their final height. Objective: To study whether neurodevelopmental and functional outcomes at the age of 19 years differ in VP and/or VLBW subjects. Methods: 705 19-year-old subjects from the Project on Preterm and Small-for-Gestational-Age Infants (POPS) cohort were classified as (1) VP+/VLBW+ (n = 354), (2) VP+/VLBW-(n = 144), or (3) VP-/VLBW+ (n = 207), and compared with regard to IQ as assessed with the Multicultural Capacity Test-intermediate level; neuromotor function using Touwen's examination of mild neurologic dysfunction; hearing loss; self-and parent-reported behavioral and emotional functioning; educational achievement and occupation; and self-assessed health using the Health Utilities Index and the London Handicap Scale. Results: VP+/VLBW-infants, on average, had 3.8-point higher IQ scores (95% confidence interval [CI] 0.57.1), a trend towards higher educational achievement, 3.3dB better hearing (95% CI 1.2-5.4), and less anxious behavior, attention problems, and internalizing behavior than to VP+/VLBW+ subjects. VP-/VLBW+ infants reported 1.8 increased odds (95% CI 1.2-2.6) of poor health compared to VP+/VLBW+ subjects. Conclusions: At the age of 19 years, subjects born VP+/VLBW+, VP+/VLBW-, and VP-/VLBW+ have different neurodevelopmental and functional outcomes, although effect sizes are small. Hence, the terms VP and VLBW are not interchangeable. We recommend, at least for industrialized countries, to base inclusion in future studies on preterm populations on GA instead of on BW. (c) 2018 The Author(s) Published by S. Karger AG, Basel

引用

页码：310 / 319

页数：10

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