Direct metal-free O-arylation of Biginelli 4-aryl-6-methyl-pyrimidine-2(1H)-one derivatives using diaryliodonium salts

被引：16
|
作者：
Thorat, Prerana B. [1 ]
Waghmode, Nitin A. [1 ]
Karade, Nandkishor N. [1 ]
机构：
[1] Rashtrasant Tukadoji Maharaj Nagpur Univ, Dept Chem, Nagpur 440033, Maharashtra, India
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 42期
关键词：
Biginelli reaction; 4-Aryl-6-methyl-pyrimidine-2(1H)-one; Heteroaryl ether; C-O cross-coupling; Diaryliodonium salts; ONE-POT SYNTHESIS; EFFICIENT; PYRIMIDINES; INHIBITORS; IODINE; OPTIMIZATION; CHEMISTRY;
D O I：
10.1016/j.tetlet.2014.08.079
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
4-Aryl-6-methyl-pyrimidine-2(1H)-one scaffolds of Biginelli type were subjected to C-O cross-coupling reactions using symmetrical diaryliodonium salts under transition metal-free conditions to afford 2-aryl-oxy pyrimidine derivatives in good to excellent yields. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5718 / 5721
页数：4
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