Formulation and Evaluation of Hydroxypropyl Methylcellulose Based Topical Gel Loaded with Ganciclovir

The study aimed to formulate topical gel to enhance the bioavailability of ganciclovir. Formulations were designed using central composite rotatable designed (CCRD) approach. The prepared formulations were subjected to various evaluation parameters including compatibility studies, permeation studies, surface morphology, X-ray diffraction and rheological studies. Considerable values of flux (6.531 +/- 0.008) have indicated significant increase in permeability of ganciclovir. Surface morphological studies have shown uniform mixing of the drug and excipients, and the claim was reinforced by the findings of XRD. Kinetic modeling has declared that the Korsmeyer-Poppas model was the dominating, predicting the diffusion type of mechanism of drug release. Conclusively, the permeable topical gel is better choice for the delivery of ganciclovir through topical route.