A simplified and scalable synthesis of artesunate

被引：15

作者：

Presser, Armin ^{[1
]}

Feichtinger, Andrea ^{[1
]}

Buzzi, Silke ^{[1
]}

机构：

[1] Graz Univ, Inst Pharmaceut Sci, Graz, Austria

来源：

MONATSHEFTE FUR CHEMIE | 2017年 / 148卷 / 01期

关键词：

Antimalarial; Peroxides; Natural products; Reductions; Green chemistry; DIHYDROARTEMISININ DERIVATIVES; ARTEMISININ DERIVATIVES; QINGHAOSU ARTEMISININ; PART I; ANTIMALARIAL; CHEMISTRY; DISCOVERY; MALARIA; DRUGS; ARTEMETHER;

D O I：

10.1007/s00706-016-1865-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and economically viable approach for the large-scale conversion of artemisinin into the antimalarial frontline drug artesunate was developed. This advanced synthesis includes an NaBH4-induced reduction, followed by an esterification with succinic anhydride under basic conditions. The entire conversion follows the principles of green chemistry, i.e., application of reusable solvents.

引用

页码：63 / 68

页数：6

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