Modulation by dietary copper of aflatoxin B-1-induced activity of DNA repair enzymes poly (ADP-ribose) polymerase, DNA polymerase beta and DNA ligase

被引：0
|
作者：
Webster, RP [1 ]
Gawde, MD [1 ]
Bhattacharya, RK [1 ]
机构：
[1] BHABHA ATOM RES CTR,RADIOL BIOL & BIOCHEM DIV,BOMBAY 400085,MAHARASHTRA,INDIA
来源：
IN VIVO | 1996年 / 10卷 / 05期
关键词：
aflatoxin B-1; DNA damage; DNA repair enzymes; copper;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The activity of some nuclear enzymes associated with DNA repair was examined following aflatoxin B-1 administration in rats maintained on different levels of dietary copper. Induction of poly(ADP-ribose) polymerase, DNA polymerase beta and DNA ligase was found to be significantly higher in copper-deficient rats. Copper supplementation, even al marginal doses, was able to bring down the induction to the level observed in normal rats. The results emphasize the protective tale of copper against the DNA damaging effects of aflatoxin B-1.
引用
收藏
页码：533 / 536
页数：4
相关论文
共 50 条
  • [1] DNA-REPAIR ENZYMES IN THE BRAIN - DNA POLYMERASE-BETA AND POLY (ADP-RIBOSE) POLYMERASE
    ZUCCONI, GG
    DEPRATI, AC
    MENEGAZZI, M
    COSI, C
    SUZUKI, H
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES, 1992, 663 : 432 - 435
  • [2] POLY(ADP-RIBOSE) POLYMERASE AND DNA
    YOSHIHARA, K
    SEIKAGAKU, 1981, 53 (07): : 528 - 534
  • [3] POLY(ADP-RIBOSE) POLYMERASE AND NUCLEAR DNA POLYMERASE
    HAINES, ME
    MATHIAS, AP
    JOHNSTON, IR
    HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1972, 353 (06): : 849 - &
  • [4] Poly(ADP-Ribose) polymerase 1 as a key regulator of DNA repair
    Khodyreva, S. N.
    Lavrik, O. I.
    MOLECULAR BIOLOGY, 2016, 50 (04) : 580 - 595
  • [5] Poly(ADP-Ribose) polymerase 1 as a key regulator of DNA repair
    S. N. Khodyreva
    O. I. Lavrik
    Molecular Biology, 2016, 50 : 580 - 595
  • [6] Targeting DNA repair: poly (ADP-ribose) polymerase inhibitors
    Frey, Melissa K.
    Pothuri, Bhavana
    TRANSLATIONAL CANCER RESEARCH, 2015, 4 (01) : 84 - 96
  • [7] DNA Repair Enzymes Promising in Cancer Therapy; Poly (ADP-Ribose) Polymerase Inhibitors
    Demir, Zehra
    Karahalil, Bensu
    GAZI MEDICAL JOURNAL, 2022, 33 (03): : 312 - 321
  • [8] Poly(ADP-ribose) polymerase 1 regulates activity of DNA polymerase β in long patch base excision repair
    Sukhanova, Maria
    Khodyreva, Svetlana
    Lavrik, Olga
    MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2010, 685 (1-2) : 80 - 89
  • [9] Inhibition of poly(ADP-ribose)polymerase-1 and DNA repair by uranium
    Cooper, Karen L.
    Dashner, Erica J.
    Tsosie, Ranalda
    Cho, Young Mi
    Lewis, Johnnye
    Hudson, Laurie G.
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2016, 291 : 13 - 20
  • [10] Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity
    Bürkle, A
    Beneke, S
    Brabeck, C
    Leake, A
    Meyer, R
    Muiras, ML
    Pfeiffer, R
    EXPERIMENTAL GERONTOLOGY, 2002, 37 (10-11) : 1203 - 1205
12345