Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody

被引：310

作者：

Corti, Davide ^{[1
,2
]}

Misasi, John ^{[3
]}

Mulangu, Sabue ^{[3
]}

Stanley, Daphne A. ^{[3
]}

Kanekiyo, Masaru ^{[3
]}

Wollen, Suzanne ^{[4
]}

Ploquin, Aurelie ^{[3
]}

Doria-Rose, Nicole A. ^{[3
]}

Staupe, Ryan P. ^{[3
]}

Bailey, Michael ^{[3
]}

Shi, Wei ^{[3
]}

Choe, Misook ^{[3
]}

Marcus, Hadar ^{[3
]}

Thompson, Emily A. ^{[3
]}

Cagigi, Alberto ^{[3
]}

Silacci, Chiara ^{[1
]}

Fernandez-Rodriguez, Blanca ^{[1
]}

Perez, Laurent ^{[1
]}

Sallusto, Federica ^{[1
]}

Vanzetta, Fabrizia ^{[2
]}

Agatic, Gloria ^{[2
]}

Cameroni, Elisabetta ^{[2
]}

Kisalu, Neville ^{[3
,5
]}

Gordon, Ingelise ^{[3
]}

Ledgerwood, Julie E. ^{[3
]}

Mascola, John R. ^{[3
]}

Graham, Barney S. ^{[3
]}

Muyembe-Tamfun, Jean-Jacques ^{[5
]}

Trefry, John C. ^{[4
]}

Lanzavecchia, Antonio ^{[1
,6
]}

Sullivan, Nancy J. ^{[3
]}

机构：

[1] Univ Svizzera Italiana, Inst Res Biomed, CH-6500 Bellinzona, Switzerland

[2] Humabs BioMed SA, CH-6500 Bellinzona, Switzerland

[3] NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA

[4] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA

[5] Natl Lab Publ Hlth, Natl Inst Biomed Res, BP 1197, Kinshasa, DEM REP CONGO

[6] ETH, Inst Microbiol, CH-8093 Zurich, Switzerland

来源：

SCIENCE | 2016年 / 351卷 / 6279期

关键词：

MONOCLONAL-ANTIBODIES; OUTBREAK; MONKEYS; DISEASE; ZAIRE;

D O I：

10.1126/science.aad5224

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ebola virus disease in humans is highly lethal, with case fatality rates ranging from 25 to 90%. There is no licensed treatment or vaccine against the virus, underscoring the need for efficacious countermeasures. We ascertained that a human survivor of the 1995 Kikwit Ebola virus disease outbreak maintained circulating antibodies against the Ebola virus surface glycoprotein for more than a decade after infection. From this survivor we isolated monoclonal antibodies (mAbs) that neutralize recent and previous outbreak variants of Ebola virus and mediate antibody-dependent cell-mediated cytotoxicity in vitro. Strikingly, monotherapy with mAb114 protected macaques when given as late as 5 days after challenge. Treatment with a single human mAb suggests that a simplified therapeutic strategy for human Ebola infection may be possible.

引用

页码：1339 / 1342

页数：4

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