Inhibition of Vascular Endothelial Growth Factor Receptor-1/Wnt/β-catenin Crosstalk Leads to Tumor Cell Death

被引：12

作者：

Zeitlin, Benjamin D. ^{[1
]}

Ellis, Lee M. ^{[4
,5
]}

Noer, Jacques E. ^{[1
,2
,3
]}

机构：

[1] Univ Michigan, Angiogenesis Res Lab, Dept Restorat Sci, Sch Dent, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Coll Engn, Dept Biomed Engn, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Otolaryngol, Sch Med, Ann Arbor, MI 48109 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA

[5] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA

来源：

CLINICAL CANCER RESEARCH | 2009年 / 15卷 / 24期

关键词：

SYNTHETIC LETHAL; CANCER-CELLS; FACTOR RECEPTOR-1; SUPPRESSION; WNT;

D O I：

10.1158/1078-0432.CCR-09-2578

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Two genes are considered synthetic lethal if mutation of either alone allows cell viability, whereas simultaneous mutation leads to cell death. A synthetic lethal screen unveiled the dependency of Wnt/beta-catenin-addicted colorectal cancer cells on vascular endothelial growth factor receptor-1 kinase activity and suggested a novel therapeutic approach for this malignancy. (Clin Cancer Res 2009;15(24):7453-5)

引用

页码：7453 / 7455

页数：3

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