Vestibular Function and Vertigo Control after Intratympanic Gentamicin for Meniere's Disease

被引：31

作者：

Nguyen, Kimanh D. ^{[1
]}

Minor, Lloyd B. ^{[1
,2
,3
]}

Della Santina, Charles C. ^{[1
,2
]}

Carey, John P. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21287 USA

[3] Johns Hopkins Univ, Dept Neurosci, Baltimore, MD 21287 USA

来源：

AUDIOLOGY AND NEURO-OTOLOGY | 2009年 / 14卷 / 06期

关键词：

Meniere's disease; Gentamicin; Angular vestibulo-ocular reflex; Caloric unilateral weakness; Vertigo; COCHLEAR IMPLANTATION; ENDOLYMPHATIC HYDROPS; HEAD; STIMULATION; THERAPY;

D O I：

10.1159/000241893

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

The aim of this study was to correlate long-term vertigo control with reduction in vestibular function after intratympanic (IT) gentamicin therapy for unilateral Meniere's disease. IT gentamicin injections were given as needed to control vertigo attacks. Vertigo frequency and changes in angular vestibulo-ocular reflex (AVOR) gain (measured using magnetic search coils and manual head thrusts) and caloric weakness were assessed before and after treatment. Better vertigo control after treatment was found with >= 60% reduction in quantitative ipsilateral horizontal semicircular canal AVOR gain from pre-treatment values and/or with caloric unilateral weakness (UW) >= 50%. However, no correlations were found between the continuous variables of vertigo control and either gain or gain recovery, nor between gain and UW because of the large variability in vertigo control in subjects with lesser reductions in these measures. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：361 / 372

页数：12

共 50 条

[1] Intratympanic gentamicin for control of vertigo in Meniere's disease: Vestibular signs that specify completion of therapy
Minor, LB
[J]. AMERICAN JOURNAL OF OTOLOGY, 1999, 20 (02): : 209 - 219
[2] Vestibular function at the end of intratympanic gentamicin treatment of patients with Meniere's disease
Perez, N
Rama-Lopez, J
[J]. JOURNAL OF VESTIBULAR RESEARCH-EQUILIBRIUM & ORIENTATION, 2005, 15 (01): : 49 - 58
[3] Results of Electrocochleography in Meniere's Disease after Successful Vertigo Control by Single Intratympanic Gentamicin Injection
Bueki, Bela
Platz, Michael
Haslwanter, Thomas
Juenger, Heinz
Avan, Paul
[J]. AUDIOLOGY AND NEURO-OTOLOGY, 2011, 16 (01) : 49 - 54
[4] Long-term vertigo control in patients after intratympanic gentamicin instillation for Meniere's disease
Bodmer, Daniel
Morong, Sharon
Stewart, Craig
Alexander, Ashlin
Chen, Joseph M.
Nedzelski, Julian M.
[J]. OTOLOGY & NEUROTOLOGY, 2007, 28 (08) : 1140 - 1144
[5] Auditory results after vestibular nerve section and intratympanic gentamicin for Meniere's disease
Colletti, Vittorio
Carner, Marco
Colletti, Liliana
[J]. OTOLOGY & NEUROTOLOGY, 2007, 28 (02) : 145 - 151
[6] Control of vertigo in Meniere's disease by intratympanic dexamethasone
Weckel, A.
Marx, M.
Esteve-Fraysse, M. -J.
[J]. EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES, 2018, 135 (01) : 7 - 10
[7] Histopathology of the vestibular end organs after intratympanic gentamicin failure for Meniere's disease
Ishiyama, Gail
Lopez, Ivan
Baloh, Robert W.
Ishiyama, Akira
[J]. ACTA OTO-LARYNGOLOGICA, 2007, 127 (01) : 34 - 40
[8] Vestibular nerve section versus intratympanic gentamicin for Meniere's disease
Hillman, TA
Chen, DA
Arriaga, MA
[J]. LARYNGOSCOPE, 2004, 114 (02): : 216 - +
[9] Intratympanic dexamethasone, intratympanic gentamicin, and endolymphatic sac surgery for intractable vertigo in Meniere's disease
Sennaroglu, L
Sennaroglu, G
Gursel, B
Dini, FM
[J]. OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2001, 125 (05) : 537 - 543
[10] Intratympanic gentamicin in Meniere's disease
Kaasinen, S
Pyykkö, I
Ishizaki, H
Aalto, H
[J]. ACTA OTO-LARYNGOLOGICA, 1998, 118 (03) : 294 - 298

← 1 2 3 4 5 →