4-aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

被引：23

作者：

Pinard, E ^{[1
]}

Alanine, A

Bourson, A

Büttelmann, B

Heitz, MP

Mutel, V

Gill, R

Trube, G

Wyler, R

机构：

[1] F Hoffmann La Roche Ltd, Div Pharma, Discovery Chem, CH-4070 Basel, Switzerland

[2] F Hoffmann La Roche Ltd, Div Pharma, Preclin CNS Res, CH-4070 Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(02)00470-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Screening of the Roche compound library led to the identification of 4-aminoquinoline 4 as structurally novel NR1/2B subtype selective NMDA receptor antagonist. The SAR which was developed in this series resulted in the discovery of highly potent and in vivo active blockers. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2615 / 2619

页数：5

共 50 条

[1] 1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists
Alanine, A
Bourson, A
Büttelmann, B
Gill, R
Heitz, MP
Mutel, V
Pinard, E
Trube, G
Wyler, R
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (19) : 3155 - 3159
[2] 2-(3,4-dihydro-1H-isoquinolin-2yl)-pyridin as a novel class of NR1/2B subtype selective NMDA receptor antagonists
Büttelmann, B
Alanine, A
Bourson, A
Gill, R
Heitz, MP
Mutel, V
Pinard, E
Trube, G
Wyler, R
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (05) : 829 - 832
[3] NR1/2B NMDA-receptor antagonist
Lloyd, AW
DRUG DISCOVERY TODAY, 1999, 4 (12) : 569 - 569
[4] NR2B subtype selective NMDA receptor antagonists.
McCauley, JA
Claiborne, CF
Theberge, CR
Romano, JJ
Billings, SB
Libby, BE
McIntyre, CJ
Anderson, KD
Michelson, SR
Claremon, DA
Freidinger, RM
Bednar, RA
Mosser, SD
Gaul, SL
Connolly, TM
Condra, CL
Xia, M
Cunningham, ME
Kiss, L
Bednar, B
Stump, GL
Lynch, JJ
Curtis, NR
Diggle, HJ
Kulagowski, JJ
Macaulay, A
Wafford, KA
Koblan, KS
Liverton, NJ
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 227 : U37 - U37
[5] Radiosynthesis and in vivo evaluation of [11C]Ro-647312:: a novel NR1/2B subtype selective NMDA receptor radioligand
Dollé, F
Valette, H
Demphel, S
Coulon, C
Ottaviani, M
Bottlaender, M
Kassiou, M
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2004, 47 (13): : 911 - 920
[6] MEDI 247-NR2B subtype selective NMDA receptor antagonists
McCauley, John A.
Bednar, Rodney A.
Bednar, Bohumil
Butcher, John W.
Claiborne, Christopher F.
Claremon, David A.
Cunningham, Michael E.
Dilella, Anthony
Fandozzi, Christine
Gaul, Stanley L.
Lyle, Elizabeth A.
Lynch, Joseph J.
McIntyre, Charles J.
Mosser, Scott D.
Nguyen, Kevin T.
Romano, Joseph J.
Schreier, John D.
Stump, Gary L.
Sun, Hong
Trainor, Nicole
Wang, Hao
Yergey, James
Koblan, Kenneth S.
Young, Steven D.
Liverton, Nigel J.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, 236
[7] Discovery of subtype-selective nmda receptor ligands: 4-benzyl-1-piperidinyalkynylpyrroles, pyrazoles and imidazoles as NR1A/2B antagonists
Wright, JL
Gregory, TF
Boxer, PA
Meltzer, LT
Serpa, KA
Wise, LD
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (19) : 2815 - 2818
[8] [3H]CGP61594:: A selective photoaffinity ligand for the glycine site of the NMDA receptor subtype NR1/2B
Honer, M
Benke, D
Kuhse, J
Laube, B
Heckendorn, R
Allgeier, H
Betz, H
Mohler, H
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1998, 358 (01) : R50 - R50
[9] 2-styryl-pyridines and 2-(3,4-dihydro-naphthalen-2-yl)-pyridines as potent NR1/2B subtype selective NMDA receptor antagonists
Buettelmann, B
Alanine, A
Bourson, A
Gill, R
Heitz, MP
Mutel, V
Pinard, E
Trube, G
Wyler, R
CHIMIA, 2004, 58 (09) : 630 - 633
[10] Oxamides as novel NR2B selective NMDA receptor antagonists
Barta-Szalai, G
Borza, I
Bozó, É
Kiss, C
Agai, B
Proszenyák, A
Keserü, GM
Gere, A
Kolok, S
Galgóczy, K
Horváth, C
Farkas, S
Domány, G
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (15) : 3953 - 3956

← 1 2 3 4 5 →