Steroidal or non-steroidal FXR agonists - Is that the question?

被引:15
|
作者
Verbeke, Len [1 ]
Nevens, Frederik [1 ]
Laleman, Wim [1 ]
机构
[1] Univ Hosp Leuven, KU Leuven, Dept Gastroenterol & Hepatol, Leuven, Belgium
关键词
D O I
10.1016/j.jhep.2017.01.013
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
引用
收藏
页码:680 / 681
页数:2
相关论文
共 50 条
  • [1] Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists
    Abel, Ulrich
    Schlueter, Thomas
    Schulz, Andreas
    Hambruch, Eva
    Steeneck, Christoph
    Hornberger, Martin
    Hoffmann, Thomas
    Perovic-Ottstadt, Sanja
    Kinzel, Olaf
    Burnet, Michael
    Deuschle, Ulrich
    Kremoser, Claus
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (16) : 4911 - 4917
  • [2] Non-steroidal glucocorticoid agonists
    不详
    [J]. EXPERT OPINION ON THERAPEUTIC PATENTS, 2005, 15 (04) : 467 - 470
  • [3] A design and iterative approach to non-steroidal and steroidal agonists
    Biggadike, Keith
    Coe, Diane M.
    Mclay, Lain M.
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 233 : 671 - 671
  • [4] Steroidal and non-steroidal FXR agonists elicit clinically-relevant lipoprotein profiles in mice with chimeric humanized livers
    Papazyan, R.
    Rigbolt, K.
    Lind, R.
    Feigh, M.
    Liu, J.
    Dong, B.
    Plummer, E.
    Lewis, R. D., II
    Roth, M.
    Young, M.
    [J]. JOURNAL OF HEPATOLOGY, 2018, 68 : S59 - S60
  • [5] Activation of FXR by steroidal or non-steroidal agonists causes an increase in LDL-cholesterol in mice with humanized chimeric liver
    Liu, X.
    Liu, J.
    Dong, B.
    Roth, J.
    Young, M.
    [J]. JOURNAL OF HEPATOLOGY, 2017, 66 (01) : S611 - S611
  • [6] Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries
    Nicolaou, KC
    Evans, RM
    Roecker, AJ
    Hughes, R
    Downes, M
    Pfefferkorn, JA
    [J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2003, 1 (06) : 908 - 920
  • [7] 3D-QSAR studies with the aid of molecular docking for a series of non-steroidal FXR agonists
    Zhang, Tao
    Zhou, Jun-Hong
    Shi, Liang-Wei
    Zhu, Rui-Xin
    Chen, Min-Bo
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (08) : 2156 - 2160
  • [8] Identification and optimization of non-steroidal glucocorticoid receptor agonists
    Thomson, David S.
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 233 : 578 - 578
  • [9] Identification of dissociated non-steroidal glucocorticoid receptor agonists
    Kuzmich, Daniel
    Kirrane, Tom
    Proudfoot, John
    Bekkali, Younes
    Zindell, Renee
    Beck, Laura
    Nelson, Richard
    Shih, Cheng-Kon
    Kukulka, Alison J.
    Paw, Zofia
    Reilly, Patty
    Deleon, Rodney
    Cardozo, Mario
    Nabozny, Gerald
    Thomson, David
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (18) : 5025 - 5031
  • [10] Recent Advances in Non-Steroidal FXR Antagonists Development for Therapeutic Applications
    Huang, Huang
    Xu, Yong
    Zhu, Jin
    Li, Jian
    [J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2014, 14 (19) : 2175 - 2187