A new chromone from the twig of Mallotus apelta

被引：14
|
作者：
Lu, Tailiang [1 ,2 ]
Deng, Shengping [1 ]
Li, Chen [1 ,2 ]
Wu, Liangdeng [1 ,2 ]
Yang, Ruiyun [1 ]
Li, Jun [1 ,2 ,3 ]
机构：
[1] Guangxi Normal Univ, Key Lab Chem & Mol Engn Med Resources, Minist Educ China, Sch Environm & Resource, Guilin 541004, Peoples R China
[2] Guangxi Normal Univ, Key Lab Ecol Rare & Endangered Species & Environm, Minist Educ China, Guilin 541004, Peoples R China
[3] Guangxi Inst Bot, Guangxi Key Lab Funct Phytochem Res & Utilizat, Guilin 541006, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2014年 / 28卷 / 21期
关键词：
Mallotus apelta; Mallotus; melachromone; chromone; cytotoxic activity; STRUCTURE ELUCIDATION; ILLICIUM-VERUM;
D O I：
10.1080/14786419.2014.951853
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new chromone, 7-hydroxy-2-hydroxymethyl-8-methoxy-4-oxo-4H-chromene-6-carboxylic acid, named melachromone, along with 13 known compounds (2-14), including chromones, flavonoids, coumarins and phenylpropane derivatives, were isolated from the twig of Mallotus apelta. Their chemical structures were elucidated by using various spectroscopic methods. Anti-tumour evaluation of the compounds suggested that compound 1 exhibited medium cytotoxic activity against KB and HeLa Cells, with IC50 values of 9.50 and 9.23 mu g mL(-1), respectively.
引用
收藏
页码：1864 / 1868
页数：5
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