Anti-inflammatory Labdane Diterpenoids from Lagopsis supina

被引：36

作者：

Li, Hui ^{[1
,2
]}

Li, Man-Man ^{[1
,2
]}

Su, Xiao-Qin ^{[1
,2
]}

Sun, Jing ^{[1
,2
]}

Gu, Yu-Fan ^{[1
,2
]}

Zeng, Ke-Wu ^{[3
]}

Zhang, Qian ^{[1
]}

Zhao, Yun-Fang ^{[1
]}

Ferreira, Daneel ^{[4
,5
]}

Zjawiony, Jordan K. ^{[4
,5
]}

Li, Jun ^{[1
]}

Tu, Peng-Fei ^{[1
]}

机构：

[1] Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China

[2] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China

[3] Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

[4] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA

[5] Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, University, MS 38677 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 04期

关键词：

SPIROLABDANE-TYPE DITERPENOIDS; LEONURUS;

D O I：

10.1021/np5001329

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ten new labdane diterpenoids, lagopsins A-H (1-3, 5, 7-10) and 15-epi-lagopsins C and D (4, 6), together with five known labdane diterpenoids (11-15), were isolated from the whole plants of Lagopsis supina. The absolute configuration of lagopsin A (1) was determined by single-crystal X-ray crystallographic analysis. Compounds 7, 9, 13, and 15 exhibited moderate inhibition of nitric oxide production stimulated by lipopolysaccharide in BV-2 microglial cells with IC50 values in the range 4.9-34.9 mu M.

引用

页码：1047 / 1053

页数：7

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