2-Aminoacetophenone Is the Main Volatile Phase I Skatole Metabolite in Pietrain x Baden-Wurttemberg Hybrid Type Boars

被引：5

作者：

Gerlach, Christoph ^{[1
]}

Elsinghorst, Paul W. ^{[2
,3
]}

Schmarr, Hans-Georg ^{[4
]}

Wuest, Matthias ^{[1
]}

机构：

[1] Univ Bonn, Dept Nutr & Food Sci, Bioanalyt, Endenicher Allee 11 13, D-53115 Bonn, Germany

[2] Univ Bonn, Inst Pharmaceut, Pharmaceut Chem 1, Immenburg 4, D-53121 Bonn, Germany

[3] ELFI Analyt GbR, Massenhausener Str 18a, D-85375 Neufahrn, Germany

[4] Dienstleistungszentrum Landlicher Raum DLR Rheinp, Competence Ctr Wine Res, Breitenweg 71, D-67435 Neustadt, Germany

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2016年 / 64卷 / 05期

关键词：

SIDA; HS-SPME/GC-MS; skatole; microsomes; metabolism; ENTIRE MALE PIGS; CHROMATOGRAPHY-MASS SPECTROMETRY; CASTRATED MALE PIGS; CYTOCHROME-P450; ENZYMES; LIVER-MICROSOMES; TAINT COMPOUNDS; PORCINE LIVER; SURGICAL CASTRATION; HEPATIC MICROSOMES; MEAT QUALITY;

D O I：

10.1021/acs.jafc.5b05729

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Skatole metabolites have been considered as putative contributors to boar taint. Recently, 2-aminoacetophenone, a volatile phase I skatole metabolite, was identified in back fat samples from boars of Pietrain X Baden-Wurttemberg hybrid type. This paper addresses the question of the physiological origin of the observed 2-aminoacetophenone in these pigs. Microsomal fractions from nine boars were isolated, and formation of skatole metabolites was subsequently analyzed by stable-isotope dilution analysis (SIDA) using headspace solid-phase microextraction gas chromatography-mass spectrometry (HS-SPME/GC-MS). Significant breed-related differences in phase I skatole metabolism were observed, explaining the high levels of 2aminoacetophenone in Pietrain x Baden-Wurttemberg hybrid type boars.

引用

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页码：1158 / 1163

页数：6

共 2 条

[1] 2-Aminoacetophenone is the main volatile phase i skatole metabolite in Pietrain × Baden-Württemberg hybrid type boars
Wüst, Matthias (matthias.wuest@uni-bonn.de), 1600, American Chemical Society (64):
[2] Pre-Exposure Prophylaxis Integration Into Family Planning Services at Title X Clinics in the Southeastern United States: Protocol for a Mixed Methods Hybrid Type I Effectiveness Implementation Study (Phase 2 ATN 155)
Sheth, Anandi N.
Hussen, Sophia A.
Escoffery, Cam
Haddad, Lisa B.
Powell, Leah
Brown, Nakita
Filipowicz, Teresa R.
McCumber, Micah
Sanchez, Maria
Renshaw, Laura
Psioda, Matthew A.
Sales, Jessica M.
JMIR RESEARCH PROTOCOLS, 2020, 9 (09):

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