Usefulness of RA and RO isoforms of common leukocyte antigen (CD45) for early distinction between normal and abnormal promyelocytes

被引：3

作者：

D'Arena, G ^{[1
]}

Cascavilla, N ^{[1
]}

Nunziata, G ^{[1
]}

Perla, G ^{[1
]}

Matera, R ^{[1
]}

Carella, AM ^{[1
]}

Pistolese, G ^{[1
]}

机构：

[1] San Giovanni di Dio & Ruggi Aragona Hosp, Dept Hematol Oncol, I-84100 Salerno, Italy

来源：

LEUKEMIA & LYMPHOMA | 2002年 / 43卷 / 09期

关键词：

promyelocytes; flow cytometry; CD45RA; CD45RO;

D O I：

10.1080/1042819021000006538

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Normal promyelocytes express CD45RO, while acute promyelocytic leukemia (APL) blasts express CD45RA, both isoforms of common leukocyte antigen with mutually exclusive expression. Here we report a patient with accumulation of promyelocytes in the bone marrow and the diagnostic strategy is described along with the ability to quickly discriminate between normal and abnormal cells using the flow cytometric detection of expression of RA/RO isoforms of CD45.

引用

页码：1823 / 1825

页数：3

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