Solid phase synthesis of 6-acylamino-1-alkyl/aryl-4-oxo-1, 4-dihydrocinnoline-3-carboxamides

被引：8

作者：

Sereni, L ^{[1
]}

Tató, M ^{[1
]}

Sola, F ^{[1
]}

Brill, WKD ^{[1
]}

机构：

[1] Nerviano Med Sci, Dept Chem, I-20014 Nerviano, MI, Italy

来源：

TETRAHEDRON | 2004年 / 60卷 / 38期

关键词：

cinnolines; solid support; alkylation; arylation; rearrangement; reduction; acylation; reaction monitoring;

D O I：

10.1016/j.tet.2004.06.103

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

6-Acylmino-1-alkyl/aryl-4-oxo-1,4-dihydrocinnoline-3-carboxamides were synthesized in parallel from 6-nitro-4-oxo-1,4-dihydrocinnoline-3-carboxylic acid. The latter formed amides with amines bound to polystyrene-based resins via acid-labile linkers. N1 and N2-alkylation, followed by alkyl migration yielded only N1-alkylated products. Reduction of the 6-nitro group and acylation concluded the synthesis. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：8561 / 8577

页数：17

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