Objectives: To determine whether retinal nerve fiber layer (RNFL) atrophy in the afferent visual pathway may complement existing tools used to describe and characterize differences across MS subtypes. Methods: Optical coherence tomography-measured RNFL values were compared over two years in 35 patients (70 eyes) with optic neuritis (ON) as a clinically isolated syndrome (CIS): 39 patients (78 eyes) with relapsing remitting MS (RRMS); and 7 patients (14 eyes) with secondary progressive MS (SPMS). Results: RNFL comparisons involving eyes without ON yielded greater differences between MS subtypes than ON-affected eyes. Overall RNFL values in non-affected eyes were reduced in SPMS patients (83.4 W), relative to CIS (101.2 mu m) (p = 0.0009), and RRMS patients (103.7 mu m) (p = 0.001); and temporal RNFL atrophy was greater in RRMS (64.4 mu m) eyes as compared to CIS eyes (73.2 mu m) (p = 0.02). In ON-affected eyes, RNFL atrophy was greater in SPMS patients (39.5 mu m) than CIS patients (58.1 mu m) (p = 0.03), and in RRMS patients (48.2 mu m) relative to CIS patients (p=0.05). RNFL values did not change significantly for any MS subtype during the two-year duration of the study. Interpretation: RNFL thickness may represent a structural marker, which can help distinguish MS subtypes, because the extent of atrophy is commensurate with disease progression. RNFL comparisons between non-affected eyes revealed greater differences between CIS, RRMS, and SPMS patients relative to ON-affected eyes, because the impact of prior ON may supplant the effects of disease subtype. (C) 2009 Elsevier B.V. All rights reserved.
机构:
Seoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul 110744, South Korea
Seoul Natl Univ Hosp, Dept Ophthalmol, Seoul 110744, South KoreaSeoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul 110744, South Korea
Cho, Bum-Joo
Park, Ki Ho
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Seoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul 110744, South Korea
Seoul Natl Univ Hosp, Dept Ophthalmol, Seoul 110744, South KoreaSeoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul 110744, South Korea
机构:
Hop Pierre Zobda Quitman, Ctr Hosp Univ Ft France, Serv Ophtalmol, BP 632, Fort De France 97261, Martinique, FranceHop Pierre Zobda Quitman, Ctr Hosp Univ Ft France, Serv Ophtalmol, BP 632, Fort De France 97261, Martinique, France
Merle, Harold
Olindo, Stephane
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Hop Pierre Zobda Quitman, Ctr Hosp Univ Ft France, Serv Neurol, Fort De France 97261, Martinique, FranceHop Pierre Zobda Quitman, Ctr Hosp Univ Ft France, Serv Ophtalmol, BP 632, Fort De France 97261, Martinique, France
Olindo, Stephane
Donnio, Angelique
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Hop Pierre Zobda Quitman, Ctr Hosp Univ Ft France, Serv Ophtalmol, BP 632, Fort De France 97261, Martinique, FranceHop Pierre Zobda Quitman, Ctr Hosp Univ Ft France, Serv Ophtalmol, BP 632, Fort De France 97261, Martinique, France
Donnio, Angelique
Beral, Laurence
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Hop Pierre Zobda Quitman, Ctr Hosp Univ Ft France, Serv Ophtalmol, BP 632, Fort De France 97261, Martinique, FranceHop Pierre Zobda Quitman, Ctr Hosp Univ Ft France, Serv Ophtalmol, BP 632, Fort De France 97261, Martinique, France
Beral, Laurence
Richer, Raymond
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Hop Pierre Zobda Quitman, Ctr Hosp Univ Ft France, Serv Ophtalmol, BP 632, Fort De France 97261, Martinique, FranceHop Pierre Zobda Quitman, Ctr Hosp Univ Ft France, Serv Ophtalmol, BP 632, Fort De France 97261, Martinique, France
Richer, Raymond
Smadja, Didier
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Hop Pierre Zobda Quitman, Ctr Hosp Univ Ft France, Serv Neurol, Fort De France 97261, Martinique, FranceHop Pierre Zobda Quitman, Ctr Hosp Univ Ft France, Serv Ophtalmol, BP 632, Fort De France 97261, Martinique, France
Smadja, Didier
Cabre, Philippe
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Hop Pierre Zobda Quitman, Ctr Hosp Univ Ft France, Serv Neurol, Fort De France 97261, Martinique, FranceHop Pierre Zobda Quitman, Ctr Hosp Univ Ft France, Serv Ophtalmol, BP 632, Fort De France 97261, Martinique, France
机构:
Buffalo Gen Hosp, Jacobs Neurol Inst, Buffalo, NY 14203 USA
Northshore Neurosci, Erie, PA 16507 USABuffalo Gen Hosp, Jacobs Neurol Inst, Buffalo, NY 14203 USA
Grazioli, Erica
Zivadinov, Robert
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SUNY Buffalo, Dept Neurol, Buffalo Neuroimaging Anal Ctr, Buffalo, NY 14203 USABuffalo Gen Hosp, Jacobs Neurol Inst, Buffalo, NY 14203 USA
Zivadinov, Robert
Weinstock-Guttman, Bianca
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Buffalo Gen Hosp, Jacobs Neurol Inst, Buffalo, NY 14203 USABuffalo Gen Hosp, Jacobs Neurol Inst, Buffalo, NY 14203 USA
Weinstock-Guttman, Bianca
Lincoff, Norah
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Buffalo Gen Hosp, Jacobs Neurol Inst, Buffalo, NY 14203 USABuffalo Gen Hosp, Jacobs Neurol Inst, Buffalo, NY 14203 USA
Lincoff, Norah
Baier, Monika
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Univ Alabama, Sch Publ Hlth, Birmingham, AL 35294 USABuffalo Gen Hosp, Jacobs Neurol Inst, Buffalo, NY 14203 USA
Baier, Monika
Wong, Jan Rang
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Buffalo Gen Hosp, Jacobs Neurol Inst, Buffalo, NY 14203 USABuffalo Gen Hosp, Jacobs Neurol Inst, Buffalo, NY 14203 USA
Wong, Jan Rang
Hussein, Sara
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SUNY Buffalo, Dept Neurol, Buffalo Neuroimaging Anal Ctr, Buffalo, NY 14203 USABuffalo Gen Hosp, Jacobs Neurol Inst, Buffalo, NY 14203 USA
Hussein, Sara
Cox, Jennifer L.
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SUNY Buffalo, Dept Neurol, Buffalo Neuroimaging Anal Ctr, Buffalo, NY 14203 USABuffalo Gen Hosp, Jacobs Neurol Inst, Buffalo, NY 14203 USA
Cox, Jennifer L.
Hojnacki, David
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Buffalo Gen Hosp, Jacobs Neurol Inst, Buffalo, NY 14203 USABuffalo Gen Hosp, Jacobs Neurol Inst, Buffalo, NY 14203 USA
Hojnacki, David
Ramanathan, Murall
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机构:
Buffalo Gen Hosp, Jacobs Neurol Inst, Buffalo, NY 14203 USA
SUNY Buffalo, Dept Pharmaceut Sci, Buffalo, NY 14260 USABuffalo Gen Hosp, Jacobs Neurol Inst, Buffalo, NY 14203 USA