Total syntheses of (±)-musellarins A-C

被引：26

作者：

Li, Zhilong ^{[1
]}

Leung, Tsz-Fai ^{[1
]}

Tong, Rongbiao ^{[1
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 75期

关键词：

DE-NOVO SYNTHESIS; CATALYZED GLYCOSYLATION REACTION; FRIEDEL-CRAFTS CYCLIZATION; DIAZONIUM SALTS; NORHALICHONDRIN-B; HECK ARYLATION; METHYL-ESTER; PALLADIUM; REDUCTION; DERIVATIVES;

D O I：

10.1039/c4cc05248j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first, diastereoselective total syntheses of musellarins A-C were achieved concisely with 7.8-9.8% yields in 15-16 steps. The key synthetic features include (i) an Achmatowicz rearrangement, Kishi reduction, and Friedel-Crafts cyclization to construct the tricyclic framework and (ii) Heck coupling of aryldiazonium salts to introduce the aryl group into the dihydropyran in a 2,6-trans fashion in the final stage of synthesis.

引用

页码：10990 / 10993

页数：4

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