Corticotrophin-releasing hormone and fetal responses in human pregnancy

被引:44
|
作者
Sandman, CA
Wadhwa, P
Glynn, L
Chicz-Demet, A
Porto, M
Garite, TJ
机构
[1] Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92697 USA
[2] Univ Kentucky, Dept Behav Sci, Lexington, KY 40535 USA
[3] Univ Calif Irvine, Dept Obstet & Gynecol, Irvine, CA 92697 USA
关键词
D O I
10.1111/j.1749-6632.1999.tb07879.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
During human pregnancy, maternal and fetal compartments of the human placenta produce and release corticotrophic-releasing hormone (CRH), Elevations of placental CRH are associated with decreased gestational length (including preterm delivery). The effects of elevated placental CRH on human fetal neurological development are not known. Pregnant women in the 31st and 32nd week of gestation consented to procedures for collection of blood and measurement of fetal heart rate (FHR) in response to a series of 40 vibroacoustic stimuli (VAS), Measures of habituation and dishabituation were calculated from the FBR. All subjects were followed to delivery. Fetuses (N = 33) of women with highly elevated CRH were least responsive (p < ,03) to stimulation after presentation of a novel (dishabituating) stimulus with control far parity, fetal gender, medical (antepartum) risk, and gestational length at term, In a larger sample (N = 156) a polynomial model predicted the pattern of FHR reactivity for the first 15 trials. Placental CRH concentration significantly predicted FHR reactivity after controlling for the effects of trial number, baseline FHR, inter-trial interval, and presence of uterine contractions. Increased maternal CRH levels were significantly related to the length of gestation after controlling for the effects of fetal gender, parity, and medical risk (p = ,05), The relationship between length of gestation and FHR was not significant suggesting separate actions of CRH on these events. Elevated placental CRH appears to accelerate certain developmental events (gestational length) and may influence the fetal nervous system. The impaired fetal responses to novelty and increased arousal observed in this study suggest that neurological systems map be targets for placental CRH during sensitive developmental periods.
引用
收藏
页码:66 / 75
页数:10
相关论文
共 50 条
  • [1] Corticotrophin-releasing hormone and human parturition
    McLean, M
    Smith, R
    [J]. REPRODUCTION, 2001, 121 (04) : 493 - 501
  • [2] Corticotrophin-releasing hormone and parturition
    McGrath, S
    Smith, R
    [J]. CLINICAL ENDOCRINOLOGY, 2001, 55 (05) : 593 - 595
  • [3] RECOVERY FROM GLUCOCORTICOID INHIBITION OF THE RESPONSES TO CORTICOTROPHIN-RELEASING HORMONE
    WATSON, AC
    ROSENFIELD, RL
    FANG, VS
    [J]. CLINICAL ENDOCRINOLOGY, 1988, 28 (05) : 471 - 477
  • [4] Role of corticotrophin-releasing hormone in the impairment of counterregulatory responses to hypoglycemia
    Flanagan, DE
    Keshavarz, T
    Evans, ML
    Flanagan, S
    Fan, XN
    Jacob, RJ
    Sherwin, RS
    [J]. DIABETES, 2003, 52 (03) : 605 - 613
  • [5] Placental Corticotrophin-Releasing Hormone is a Modulator of Fetal Liver Blood Perfusion
    Ikenoue, Satoru
    Waffarn, Feizal
    Ohashi, Masanao
    Tanaka, Mamoru
    Gillen, Daniel L.
    Buss, Claudia
    Entringer, Sonja
    Wadhwa, Pathik D.
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2021, 106 (03): : 646 - 653
  • [6] Human fetal and maternal corticotrophin releasing hormone responses to acute stress
    Gitau, R
    Fisk, NM
    Glover, V
    [J]. ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 2004, 89 (01): : F29 - F32
  • [7] Maternal corticotrophin-releasing hormone levels during pregnancy and offspring adiposity
    Gillman, M
    Rich-Edwards, J
    Huh, S
    Majzoub, J
    Oken, E
    Taveras, E
    Rifas-Shiman, S
    [J]. OBESITY RESEARCH, 2005, 13 : A156 - A156
  • [9] The regulation of human corticotrophin-releasing hormone gene expression in the placenta
    King, BR
    Smith, R
    Nicholson, RC
    [J]. PEPTIDES, 2001, 22 (05) : 795 - 801
  • [10] Placental corticotrophin-releasing hormone (pCRH) as a possible modulator of human fetal liver blood perfusion
    Ikenoue, Satoru
    Waffarn, Feizal
    Ohashi, Masanao
    Sumiyoshi, Kaeko
    Ikenoue, Chigusa
    Buss, Claudia
    Entringer, Sonja
    Wadhwa, Pathik D.
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2019, 220 (01) : S677 - S678